3'-(benzyloxy)-[1,1'-biphenyl]-2-carboxylic acid | 893736-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3'-(benzyloxy)-[1,1'-biphenyl]-2-carboxylic acid
• 英文别名: 2-(3-Benzyloxyphenyl)benzoic acid；2-(3-phenylmethoxyphenyl)benzoic acid
• CAS: 893736-32-8
• 化学式: C₂₀H₁₆O₃
• 分子量: 304.345
• InChiKey: BFTHGUZZCJYQOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3'-(benzyloxy)-[1,1'-biphenyl]-2-carboxylic acid 在 copper diacetate 、 过氧化苯甲酰 作用下， 反应 12.0h， 生成 2-(benzyloxy)-6H-benzo[c]chromen-6-one 、
  参考文献：
  名称：

  Cu-Catalyzed Mild C(sp²)–H Functionalization Assisted by Carboxylic Acids en Route to Hydroxylated Arenes

  摘要：

  A formal Cu-catalyzed C(sp(2))-H hydroxylation assisted by benzoic acids is described. The procedure is characterized by its mild reaction conditions and wide substrate scope utilizing simple and cheap Cu catalysts, thus becoming a user-friendly and operationally simple protocol for C(sp(2))-H hydroxylation.

  DOI：

  10.1021/ja4047894

文献信息

• Mild ArI-Catalyzed C(sp²)H or C(sp³)H Functionalization/CO Formation: An Intriguing Catalyst-Controlled Selectivity Switch
  作者：Xueqiang Wang、Joan Gallardo-Donaire、Ruben Martin

  DOI：10.1002/anie.201407011

  日期：2014.10.6

  A tandem C(sp2)H and C(sp3)H functionalization/CO bond formation catalyzed by iodine(III) reagents generated in situ has been developed. The method shows wide scope under mild conditions and exhibits an unprecedented selectivity profile that can be switched depending on the catalyst employed.

  C（SP A串联2） H和C（SP 3） ħ官能/ C 由碘催化O键形成原位产生（III）的试剂已经被开发出来。该方法在温和条件下显示范围广，并且显示出前所未有的选择性曲线，可以根据所用催化剂进行切换。
• INHIBITORS OF PRENYL-PROTEIN TRANSFERASE
  申请人：MERCK & CO., INC.

  公开号：EP1091736A1

  公开（公告）日：2001-04-18
• EP1091736A4
  申请人：——

  公开号：EP1091736A4

  公开（公告）日：2001-10-24
• [EN] INHIBITORS OF PRENYL-PROTEIN TRANSFERASE<br/>[FR] INHIBITEURS DE PRENYL-PROTEINE TRANSFERASE
  申请人：MERCK & CO INC

  公开号：WO2000001382A1

  公开（公告）日：2000-01-13

  The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.