linderaggrine A

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: linderaggrine A
• 英文别名: (4-hydroxyphenyl)-(6-hydroxy-9H-pyrido[3,4-b]indol-1-yl)methanone
• 化学式: C₁₈H₁₂N₂O₃
• 分子量: 304.305
• InChiKey: IXVROTRRNKELDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (6-methoxy-9H-β-carbolin-1-yl)(4-methoxyphenyl)methanone 在 氢溴酸 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 24.0h， 以30%的产率得到linderaggrine A
  参考文献：
  名称：

  Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

  摘要：

  Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.10.126