1,4-bis(2-(bromomethyl)phenoxy)butane | 112666-86-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,4-bis(2-(bromomethyl)phenoxy)butane
• 英文别名: 1,1'-[Butane-1,4-diylbis(oxy)]bis[2-(bromomethyl)benzene]；1-(bromomethyl)-2-[4-[2-(bromomethyl)phenoxy]butoxy]benzene
• CAS: 112666-86-1
• 化学式: C₁₈H₂₀Br₂O₂
• 分子量: 428.164
• InChiKey: XSMRNKJYFIOVNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-bis(2-(bromomethyl)phenoxy)butane 、 1-(4-(pyren-1-ylmethoxy)butyl)-4-aza-1-azoniabicyclo[2.2.2]octane 以 乙腈 为溶剂， 反应 12.0h， 以60%的产率得到4,4'-(2,2'-(butane-1,4-diylbis(oxy))bis(2,1-phenylene))bis(methylene)bis(1-(4-(pyren-1-ylmethoxy)butyl)-1,4-diazonia-bicyclo[2.2.2]octane)
  参考文献：
  名称：

  1,4-Diazobicyclo(2,2,2)octane-modified multi-ammonium derivatives as ratiometric fluorescent sensors for lipopolysaccharide

  摘要：

  A series of pyrene derivatives bearing multi-quaternary ammonium 1,4-diazobicyclo(2,2,2)octane groups were synthesised as ratiometric fluorescent sensors for lipopolysaccharide (LPS) in aqueous solution. Ratiometric changes in fluorescence spectra of the sensors were observed from the pyrene monomerexcimer conversion which is modulated by the supramolecular self-assembly between sensors and LPS. These sensors show high selectivity towards LPS with the detection limit down to tens of nanomolar levels. The interaction mechanism between the sensors and LPS was also discussed.

  DOI：

  10.1080/10610278.2012.732224
• 作为产物：
  描述：

  1-甲基-2-[4-(2-甲基苯氧基)丁氧基]苯 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 反应 1.0h， 以24%的产率得到1,4-bis(2-(bromomethyl)phenoxy)butane
  参考文献：
  名称：

  1,4-Diazobicyclo(2,2,2)octane-modified multi-ammonium derivatives as ratiometric fluorescent sensors for lipopolysaccharide

  摘要：

  A series of pyrene derivatives bearing multi-quaternary ammonium 1,4-diazobicyclo(2,2,2)octane groups were synthesised as ratiometric fluorescent sensors for lipopolysaccharide (LPS) in aqueous solution. Ratiometric changes in fluorescence spectra of the sensors were observed from the pyrene monomerexcimer conversion which is modulated by the supramolecular self-assembly between sensors and LPS. These sensors show high selectivity towards LPS with the detection limit down to tens of nanomolar levels. The interaction mechanism between the sensors and LPS was also discussed.

  DOI：

  10.1080/10610278.2012.732224

文献信息

• 1,4-Diazobicyclo(2,2,2)octane-modified multi-ammonium derivatives as ratiometric fluorescent sensors for lipopolysaccharide
  作者：Wenwen Zhao、Jiasheng Wu、Weimin Liu、Pengfei Wang

  DOI：10.1080/10610278.2012.732224

  日期：2013.2

  A series of pyrene derivatives bearing multi-quaternary ammonium 1,4-diazobicyclo(2,2,2)octane groups were synthesised as ratiometric fluorescent sensors for lipopolysaccharide (LPS) in aqueous solution. Ratiometric changes in fluorescence spectra of the sensors were observed from the pyrene monomerexcimer conversion which is modulated by the supramolecular self-assembly between sensors and LPS. These sensors show high selectivity towards LPS with the detection limit down to tens of nanomolar levels. The interaction mechanism between the sensors and LPS was also discussed.