(2S,3R)-2-(3-Hydroxy-propyl)-tetrahydro-pyran-3-ol | 97102-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (2S,3R)-2-(3-Hydroxy-propyl)-tetrahydro-pyran-3-ol
• 英文别名: (2S,3R)-2-(3-hydroxypropyl)oxan-3-ol
• CAS: 97102-44-8
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: HNQSVHWZABMZAE-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S,3R)-2-(3-Hydroxy-propyl)-tetrahydro-pyran-3-ol 在 Celite 、 甲基磺酰氯 、 三乙胺 、 silver carbonate 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 (4aS,8aR)-6-(2-[1,3]Dioxolan-2-yl-ethyl)-2,3,4,4a,8,8a-hexahydro-pyrano[3,2-b]pyran
  参考文献：
  名称：

  Methods for pyranoannulation: an approach to a new class of polyethers

  摘要：

  Several methods have been developed for fusing a pyran ring to an existing pyran ring structure such that the ring oxygens assume a vicinal (ethylene glycol) relationship. The tricyclic structure 13, a previously unknown substance, was prepared through a combination of these methods.

  DOI：

  10.1021/jo00216a049
• 作为产物：
  描述：

  6-Allyl-3,4-dihydro-2H-pyran 在 三氟化硼四氢呋喃络合物 、 hydroxide 、 双氧水 作用下， 生成 (2S,3R)-2-(3-Hydroxy-propyl)-tetrahydro-pyran-3-ol
  参考文献：
  名称：

  Methods for pyranoannulation: an approach to a new class of polyethers

  摘要：

  Several methods have been developed for fusing a pyran ring to an existing pyran ring structure such that the ring oxygens assume a vicinal (ethylene glycol) relationship. The tricyclic structure 13, a previously unknown substance, was prepared through a combination of these methods.

  DOI：

  10.1021/jo00216a049

文献信息

• Methods for pyranoannulation: an approach to a new class of polyethers
  作者：Alan P. Kozikowski、Arun K. Ghosh

  DOI：10.1021/jo00216a049

  日期：1985.8

  Several methods have been developed for fusing a pyran ring to an existing pyran ring structure such that the ring oxygens assume a vicinal (ethylene glycol) relationship. The tricyclic structure 13, a previously unknown substance, was prepared through a combination of these methods.