2-(dicyclohexylphosphinyl)-benzaldoxime | 861805-97-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(dicyclohexylphosphinyl)-benzaldoxime
• 英文别名: N-{[2-(Dicyclohexylphosphoryl)phenyl]methylidene}hydroxylamine；N-[(2-dicyclohexylphosphorylphenyl)methylidene]hydroxylamine
• CAS: 861805-97-2
• 化学式: C₁₉H₂₈NO₂P
• 分子量: 333.411
• InChiKey: MWZFQXCFKCKIIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(dicyclohexylphosphino)-benzaldehyde 在 盐酸羟胺 、 双氧水 、 碳酸氢钠 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 2.0h， 生成 2-(dicyclohexylphosphinyl)-benzaldoxime
  参考文献：
  名称：

  Mild and efficient copper-catalyzed N-arylation of alkylamines and N–H heterocycles using an oxime-phosphine oxide ligand

  摘要：

  A mild and efficient copper-catalyzed system for N-arylation of alkylamines and N-H heterocycles with aryl iodides using a novel, readily prepared and highly stable oxime-functionalized phosphine oxide ligand was developed. The coupling reactions could even be performed in solvent-free conditions with moderate to good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.04.053

文献信息

• Mild and efficient copper-catalyzed N-arylation of alkylamines and N–H heterocycles using an oxime-phosphine oxide ligand
  作者：Lei Xu、Di Zhu、Fan Wu、Rongliang Wang、Boshun Wan

  DOI：10.1016/j.tet.2005.04.053

  日期：2005.7

  A mild and efficient copper-catalyzed system for N-arylation of alkylamines and N-H heterocycles with aryl iodides using a novel, readily prepared and highly stable oxime-functionalized phosphine oxide ligand was developed. The coupling reactions could even be performed in solvent-free conditions with moderate to good yields. (c) 2005 Elsevier Ltd. All rights reserved.