N-(4-nitrophenyl)hydroxylamine;hydrochloride | 1260495-42-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-nitrophenyl)hydroxylamine;hydrochloride
• CAS: 1260495-42-8
• 化学式: C₆H₆N₂O₃*ClH
• 分子量: 190.586
• InChiKey: FBFGGZGPYYCXHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.82
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.1
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(4-nitrophenyl)hydroxylamine;hydrochloride 、 丁炔二酸二乙酯 在 碳酸氢钠 作用下， 反应 0.03h， 以88%的产率得到tetramethyl 1-(p-nitrophenyl)pyrrole-2,3,4,5-tetracarboxylate
  参考文献：
  名称：

  Conventional and Microwave-Assisted Facile One-Pot Synthesis of N-Substituted Pyrrole-2,3,4,5-tetracarboxylates Under Neat Conditions

  摘要：

  Highly substituted pyrroles 3a,f were prepared conveniently in a reaction of (dimethyl- and diethyl-)acethylenedicarboxylates 1a-b with N-(methyl- and aryl-) hydroxylamines 2a-d in the presence of NaHCO3 using both conventional heating and microwave irradiation. Excelent yields of the very pure products were isolated under solvent-free conditions both at classical as well as microwave heating.

  DOI：

  10.1080/00397910903531680