(Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)-1,4-diazepan-1-yl)-N-(4-methoxybenzyl)-4-oxobut-2-enamide | 1224255-44-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)-1,4-diazepan-1-yl)-N-(4-methoxybenzyl)-4-oxobut-2-enamide
• 英文别名: (Z)-4-[4-[(4-chlorophenyl)-phenylmethyl]-1,4-diazepan-1-yl]-N-[(4-methoxyphenyl)methyl]-4-oxobut-2-enamide
• CAS: 1224255-44-0
• 化学式: C₃₀H₃₂ClN₃O₃
• 分子量: 518.055
• InChiKey: DROKJYUWWSMRQM-MSUUIHNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  61.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-[(4-氯苯基)苯基甲基]六氢-1H-1,4-二氮杂卓 、 (Z)-3-(4-甲氧基苄基氨基甲酰基)丙烯酸 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以52%的产率得到(Z)-4-(4-((4-chlorophenyl)(phenyl)methyl)-1,4-diazepan-1-yl)-N-(4-methoxybenzyl)-4-oxobut-2-enamide
  参考文献：
  名称：

  Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity

  摘要：

  A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl) methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)but-2-enamide showed most favorable bradykinin inhibitory activity and demonstrated analgesic efficacies in the rat models of inflammatory and neuropathic pain. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.01.050

文献信息

• Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity
  作者：Yoo Lim Kam、Hee-Kyung Rhee、Hwa-Jung Kim、Seung Keun Back、Heung Sik Na、Hea-Young Park Choo

  DOI：10.1016/j.bmc.2010.01.050

  日期：2010.3

  A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl) methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)but-2-enamide showed most favorable bradykinin inhibitory activity and demonstrated analgesic efficacies in the rat models of inflammatory and neuropathic pain. (C) 2010 Published by Elsevier Ltd.