bisphenol A mono-tert-butyl ether | 1220120-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bisphenol A mono-tert-butyl ether
• 英文别名: 4-[2-[4-[(2-Methylpropan-2-yl)oxy]phenyl]propan-2-yl]phenol
• CAS: 1220120-61-5
• 化学式: C₁₉H₂₄O₂
• 分子量: 284.398
• InChiKey: DJINRFDWEVVQDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  bisphenol A tert-butyl methyl ether 在 碘代三甲硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以88%的产率得到bisphenol A mono-tert-butyl ether
  参考文献：
  名称：

  氢硅烷并不总是羰基化合物的还原剂，II：氨基甲酸酯、碳酸酯、酯和醚中叔丁基的钌催化脱保护

  摘要：

  氢硅烷作为一种试剂，通过三钌簇的催化裂解氨基甲酸酯、碳酸酯、酯和醚中 OtBu 基团的 C-O 键。该反应提供了一种在中性条件下对 OtBu 基团进行脱保护的新方法，显示出使用传统布朗斯台德或路易斯酸性促进剂从未实现过的独特选择性。在 NMR 光谱分析的基础上讨论了 C-O 裂解的可能机制。

  DOI：

  10.1002/ejoc.200901279

文献信息

• [EN] THERMOSETTING RESIN COMPOSITIONS<br/>[FR] COMPOSITIONS DE RÉSINE THERMODURCISSABLE
  申请人：HEXCEL COMPOSITES LTD

  公开号：WO2017108946A1

  公开（公告）日：2017-06-29

  Meta and para alkenyl phenols are reacted with hydroxyl benzophenone to produce compounds of the genera formula or which are used as curatives for polymaleimide resins.

  甲基和对烯基酚与羟基苯甲酮反应，产生通式化合物，用作聚马来酰亚胺树脂的固化剂。
• COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS
  申请人：Charmot Dominique

  公开号：US20120263670A1

  公开（公告）日：2012-10-18

  The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

  本公开涉及化合物和方法，用于治疗与液体潴留或盐过载相关的疾病，如心力衰竭（特别是充血性心力衰竭）、慢性肾脏病、终末期肾脏病、肝病和过氧化物酶体增殖物激活受体（PPAR）γ激动剂引起的液体潴留。本公开还涉及化合物和方法，用于治疗高血压。本公开还涉及化合物和方法，用于治疗胃肠道疾病，包括治疗或减轻与胃肠道疾病相关的疼痛。
• COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDER
  申请人：Ardelyx, Inc.

  公开号：US20150190389A1

  公开（公告）日：2015-07-09

  The present disclosure is directed to compounds of the structure (X): CoreL-NHE) n (X) wherein: n is 2 or 3; NHE has the structure wherein: R 1 is H or —SO 2 —NR 7 R 8 —; R 2 is selected from H, —NR 7 (CO)R 8 , —SO 2 —NR 7 R 8 — and —NR 7 R 8 ; R 3 is hydrogen; R 7 is hydrogen; R 8 is a bond linking to L; L is a polyalkylene glycol linker; and Core has the following structure: wherein: X is selected from the group consisting of a bond, —O—, —NH—, NHC(═O)—, —NHC(═O)NH— and —NHSO 2 —; and Y is selected from the group consisting of a bond, optionally substituted C 1-6 alkylene, optionally substituted benzene, pyridinyl, a polyethylene glycol linker and —(CH 2 ) 1-6 O(CH 2 ) 1-6 —, and methods of using such compounds for the treatment of irritable bowel syndrome, chronic kidney disease and end-stage renal disease.

  本公开涉及结构为（X）：CoreL-NHE)n（X）的化合物，其中：n为2或3；NHE具有以下结构：其中：R1为H或—SO2—NR7R8—；R2选自H，—NR7（CO）R8，—SO2—NR7R8—和—NR7R8；R3为氢；R7为氢；R8为连接到L的键；L为多聚乙二醇连接剂；Core具有以下结构：其中：X选自由键，—O—，—NH—，NHC（═O）—，—NHC（═O）NH—和—NHSO2—；Y选自键，可选择性地取代的C1-6烷基，可选择性地取代的苯，吡啶基，聚乙二醇连接剂和—（CH2）1-6O（CH2）1-6—，以及使用这种化合物治疗肠易激综合征、慢性肾脏病和终末期肾脏疾病的方法。
• TROPANE DERIVATIVES USEFUL AS PESTICIDES
  申请人：Selles Patrice

  公开号：US20100331348A1

  公开（公告）日：2010-12-30

  Compounds of formula (I) wherein the substituents have the meanings assigned to them in claim 1, are useful as pesticides.

  式(I)中的化合物，其中取代基具有在权利要求书1中分配给它们的含义，可用作杀虫剂。
• POLYCARBONATE RESIN, COATING LIQUID CONTAINING SAME, AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE BODY
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：EP2378363A1

  公开（公告）日：2011-10-19

  Provided are: a urethane-based polycarbonate resin, including a repeating unit represented by the general formula [1], and a repeating unit represented by the general formula [2], in which the urethane-based polycarbonate resin has high wear resistance by virtue of a strong hydrogen bond between urethane groups; and an electrophotographic photoconductor, including a photosensitive layer provided on a conductive substrate, in which the electrophotographic photoconductor includes the above-mentioned polycarbonate resin as a component of the photosensitive layer, has high wear resistance, and maintains an excellent electrophotographic characteristic over a long time period: [Chem. 1] (Ar2 represents a group having a divalent aromatic group, and Ar1 represents a divalent aromatic group-containing group having a specific structure).

  提供了一种氨基甲酸酯基聚碳酸酯树脂，包括由通式[1]表示的重复单元和由通式[2]表示的重复单元，其中氨基甲酸酯基聚碳酸酯树脂凭借氨基甲酸酯基团之间的强氢键具有高耐磨性；以及一种电致发光感光元件，包括设置在导电基板上的感光层，其中电致发光感光元件包括作为感光层成分的上述聚碳酸酯树脂，具有高耐磨性，并能长期保持优异的电致发光特性：[化学式 1] （Ar2 代表具有二价芳香基的基团，Ar1 代表具有特定结构的含二价芳香基的基团）。