KF 25711 | 1178898-11-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: KF 25711
• 英文别名: radicicol 10-(Z)-O-methyloxime；(4R,6R,8R,9Z,11E,13Z)-16-chloro-17,19-dihydroxy-13-methoxyimino-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaen-2-one
• CAS: 1178898-11-7
• 化学式: C₁₉H₂₀ClNO₆
• 分子量: 393.824
• InChiKey: NAFCPJAGNZDFOZ-DPSGCUBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  甲氧基胺盐酸盐 、 根赤壳菌素 在 吡啶 作用下， 反应 5.5h， 以19.9%的产率得到KF 25711
  参考文献：
  名称：

  Synthesis and structure–activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity

  摘要：

  WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for inhibitors of WNT-5A expression. We identified radicicol (1) as an active compound, and synthesized several radicicol derivatives. Among them, 6,7-dihydro-10 alpha-hydroxy radicicol (31) was found to function as a new potent WNT-5A expression inhibitor with relatively low toxicity and excellent stability. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.04.060

文献信息

• Radicicol Derivatives Useful for Position Emission Tomography
  申请人：Auberson Yves

  公开号：US20080311038A1

  公开（公告）日：2008-12-18

  The present invention relates to novel radicicol derivatives of the formula I, in which R is R′, (CH 2 ) n COOR′ or (CH 2 ) n CONHR′, wherein R′ is 11 CH 3 , [ 3 H] 3 C, [ 3 H] 2 HC, [ 3 H]H 2 C or (CH 2 ) n Hal, wherein Hal is 123 I, 125 I, 131 I, I, 75 Br, 76 Br, 77 Br, 82 Br, Br, 18 F or F, or R′ is (CH 2 ) n-1 [ 3 H]HCHal or (CH 2 ) n-1 [ 3 H] 2 CHal, wherein Hal is I, Br or F, and n is, each independently, 1, 2, 3 or 4, in free form or in salt form, to their preparation, to their use as radiotracers/markers and to compositions containing them.
• Synthesis and structure–activity relationships of radicicol derivatives and WNT-5A expression inhibitory activity
  作者：Hideki Shinonaga、Toshiya Noguchi、Akiko Ikeda、Mari Aoki、Natsuko Fujimoto、Akira Kawashima

  DOI：10.1016/j.bmc.2009.04.060

  日期：2009.7

  WNT-5A, a secretory glycoprotein, is related to the proliferation of dermal papilla cells. To develop a hair-growth stimulant, we have been searching for inhibitors of WNT-5A expression. We identified radicicol (1) as an active compound, and synthesized several radicicol derivatives. Among them, 6,7-dihydro-10 alpha-hydroxy radicicol (31) was found to function as a new potent WNT-5A expression inhibitor with relatively low toxicity and excellent stability. (C) 2009 Elsevier Ltd. All rights reserved.