N-(4-chlorobenzyl)-4-methoxy-N-(2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)benzamide | 1187843-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorobenzyl)-4-methoxy-N-(2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)benzamide
• 英文别名: N-[(4-chlorophenyl)methyl]-4-methoxy-N-(2-phenyl-4-thiophen-2-yl-1,3-thiazol-5-yl)benzamide
• CAS: 1187843-71-5
• 化学式: C₂₈H₂₁ClN₂O₂S₂
• 分子量: 517.072
• InChiKey: ADHHAWGHNMLUOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  98.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (4-氯苄基)-(2-苯基-4-(噻吩-2-基)噻唑-5-基)胺 、 对甲氧基苯甲酰氯 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以108 mg的产率得到N-(4-chlorobenzyl)-4-methoxy-N-(2-phenyl-4-(thiophen-2-yl)thiazol-5-yl)benzamide
  参考文献：
  名称：

  Ugi Reactions with Ammonia Offer Rapid Access to a Wide Range of 5-Aminothiazole and Oxazole Derivatives

  摘要：

  A series of Ugi reactions has been successfully performed using ammonia as the amine component, employing 2,2,2-trifluoroethanol its a non-nucleophilic solvent in order to suppress known side reactions. Utilizing concentrated aqueous ammonia its it convenient Source, this approach offered a simple, one-step assembly of Ugi adducts suitable for elaboration into it variety of 5-aminoazole compounds through postcondensation modifications. Free or N-substituted 5-aminothiazoles and 5-(trifluoroacetamido)oxazoles were all prepared by this improved methodology. The scope of the synthetic route developed and application of the different products are discussed.

  DOI：

  10.1021/jo9014529