8-[2-(4-Chlorophenyl)sulfanylanilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide | 1034616-76-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 8-[2-(4-Chlorophenyl)sulfanylanilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide
• 英文别名: 8-[2-(4-chlorophenyl)sulfanylanilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide
• CAS: 1034616-76-6
• 化学式: C₂₃H₁₉ClN₆OS
• 分子量: 462.962
• InChiKey: GUZZMVWYVXJQQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 C₄₆H₄₁N₆O₄Pol 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 、 5-((R)-2-benzyloxymethyl-4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 1-Methyl-8-(2-pyrazol-1-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-(2-Imidazol-1-ylanilino)-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-(2-Butan-2-ylanilino)-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 1-Methyl-8-(2-prop-1-en-2-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 1-Methyl-8-(2-thiophen-2-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 、 methyl-4-[(3-aminoformyl-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-yl)amino]-3-methylbenzoate 、 、 、 、 1-Methyl-8-[2-(5-methylfuran-2-yl)anilino]-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 1-Methyl-8-(2-phenylmethoxyanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-[2-(4-Chlorophenyl)sulfanylanilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-[2-(4-Chlorophenyl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-[2-(3-Chlorophenyl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-[2-(3-Fluorophenyl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 1-Methyl-8-(2-pyrrolidin-1-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 、 8-[2-(Benzenesulfonyl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 1-Methyl-8-(2-piperidin-1-ylanilino)-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-[2-(3-Acetylphenyl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 8-[2-(4-Chloroanilino)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、 Methyl 3-[2-[(3-carbamoyl-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazolin-8-yl)amino]phenyl]benzoate 、 8-[2-(4-Acetylpiperazin-1-yl)anilino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide 、
  参考文献：
  名称：

  WO2008/74788

  摘要：

  公开号：