methyl 2-(3-fluoro-4-nitrophenyl)-2-methylpropanoate | 755031-25-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-(3-fluoro-4-nitrophenyl)-2-methylpropanoate
• CAS: 755031-25-5
• 化学式: C₁₁H₁₂FNO₄
• 分子量: 241.219
• InChiKey: UWCTVYPTNCJMCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 2-(3-fluoro-4-nitrophenyl)-2-methylpropanoate 在 氨 作用下， 以 甲醇 为溶剂， 以58%的产率得到methyl 2-(3-amino-4-nitrophenyl)-2-methylpropanoate
  参考文献：
  名称：

  [EN] HETEROCYCLIC KINASE INHIBITORS
  [FR] INHIBITEURS DE KINASE HETEROCYCLIQUE

  摘要：

  具有公式(I)的化合物对于抑制蛋白激酶是有用的。还公开了制造这些化合物的方法、包含这些化合物的组合物以及使用这些化合物的治疗方法。

  公开号：

  WO2004076424A1

文献信息

• Heterocyclic kinase inhibitors
  申请人：——

  公开号：US20040254159A1

  公开（公告）日：2004-12-16

  Compounds having the formula 1 are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有1式的化合物对于抑制蛋白激酶非常有用。还揭示了制备该化合物的方法，含有该化合物的组合物，以及使用该化合物进行治疗的方法。
• Heterocyclic Kinase Inhibitors
  申请人：Hasvold A. Lisa

  公开号：US20070254867A1

  公开（公告）日：2007-11-01

  Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

  具有公式的化合物对于抑制蛋白激酶很有用。还公开了制备这些化合物的方法、含有这些化合物的组合物和使用这些化合物的治疗方法。
• α-Substituted N-(4-tert-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists
  作者：Jae-Uk Chung、Su Yeon Kim、Ju-Ok Lim、Hyun-Kyung Choi、Sang-Uk Kang、Hae-Seok Yoon、HyungChul Ryu、Dong Wook Kang、Jeewoo Lee、Bomi Kang、Sun Choi、Attila Toth、Larry V. Pearce、Vladimir A. Pavlyukovets、Daniel J. Lundberg、Peter M. Blumberg

  DOI：10.1016/j.bmc.2007.06.041

  日期：2007.9

  A series of alpha-Substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. alpha-Methyl substituted analogues showed potent and stereospecific antagonism to the action of capsaicin on rat TRPV1 heterologously expressed in Chinese hamster ovary cells. In particular, compounds 14 and 18, which possess the R-configuration, exhibited excellent potencies (respectively, K-i = 41 and 39.2 nM and K-i(ant) = 4.5 and 37 nM). (c) 2007 Published Elsevier Ltd.
• 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS
  申请人：AbbVie Inc.

  公开号：EP1606268B1

  公开（公告）日：2015-05-20
• BENZIMIDAZOLE DERIVATIVES USEFUL AS CB-1 INVERSE AGONISTS
  申请人：Janssen Pharmaceutica NV

  公开号：US20170057929A1

  公开（公告）日：2017-03-02

  The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.