2-Amino-5-phenylbenzenesulfonamide | 686265-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Amino-5-phenylbenzenesulfonamide
• CAS: 686265-46-3
• 化学式: C₁₂H₁₂N₂O₂S
• 分子量: 248.305
• InChiKey: VRCAWFNQZWPCFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Amino-5-phenylbenzenesulfonamide 、 苯甲醇 在 水 、 palladium diacetate 、 sodium 3-(diphenylphosphanyl)benzenesulfonate 作用下， 反应 16.0h， 以89%的产率得到3,7-diphenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide
  参考文献：
  名称：

  Ñ -Benzylation /苄型CH酰胺化级联由（η 3 -苄基）钯系统在水介质：一种有效的途径为直接构建3-苯基-3,4-二氢- （2 ħ）-1,2,4- -苯并噻二嗪1,1-二氧化物

  摘要：

  AbstractWe demonstrate a unique strategy for a benzylation/benzylic CH amidation cascade reaction by the (η3‐benzyl)palladium system derived from a palladium catalyst and benzyl alcohol. This tandem process is devised as a new synthetic route for 3‐phenyl‐3,4‐dihydro‐(2H)‐1,2,4‐benzothiadiazine‐1,1‐dioxide. Water plays an important role for the smooth generation of the (η3‐benzyl)palladium species, and a bis‐benzylated Pd(II) intermediate would be formed in our catalytic system. Atom economical processes such as benzylic CH activation, cascade reactions and chemoselective reactions in aqueous media have been developed.magnified image

  DOI：

  10.1002/adsc.201300317

文献信息

• Anti-infective agents
  申请人：——

  公开号：US20040087577A1

  公开（公告）日：2004-05-06

  Compounds having the formula 1 are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

  具有公式1的化合物是丙型肝炎（HCV）聚合酶抑制剂。还公开了一种用于抑制丙型肝炎（HCV）聚合酶的组成和方法，用于制造这些化合物的过程，以及在这些过程中使用的合成中间体。
• ANTI-INFECTIVE AGENTS
  申请人：ABBOTT LABORATORIES

  公开号：EP1560827B1

  公开（公告）日：2010-12-29
• US7902203B2
  申请人：——

  公开号：US7902203B2

  公开（公告）日：2011-03-08
• [EN] ANTI-INFECTIVE AGENTS<br/>[FR] AGENTS ANTI-INFECTIEUX
  申请人：ABBOTT LAB

  公开号：WO2004041818A1

  公开（公告）日：2004-05-21

  The present invention provides an HCV polymerase inhibiting compound having the formula (I) and a composition comprising a therapeutically effective amount of said compound. The present invention also provides a method for inhibiting hepatitis C virus (HCV) polymerase, a method for inhibiting HCV viral replication, and a method for treating or preventing HCV infection. Processes for making said compounds, and synthetic intermediates employed in said processes, are also provided.
• <i>N</i>-Benzylation/Benzylic CH Amidation Cascade by the (η³-Benzyl)palladium System in Aqueous Media: An Effective Pathway for the Direct Construction of 3-Phenyl-3,4-dihydro- (2<i>H</i>)-1,2,4-benzothiadiazine 1,1-Dioxides
  作者：Hidemasa Hikawa、Naoya Matsuda、Hideharu Suzuki、Yuusaku Yokoyama、Isao Azumaya

  DOI：10.1002/adsc.201300317

  日期：2013.8.12

  AbstractWe demonstrate a unique strategy for a benzylation/benzylic CH amidation cascade reaction by the (η3‐benzyl)palladium system derived from a palladium catalyst and benzyl alcohol. This tandem process is devised as a new synthetic route for 3‐phenyl‐3,4‐dihydro‐(2H)‐1,2,4‐benzothiadiazine‐1,1‐dioxide. Water plays an important role for the smooth generation of the (η3‐benzyl)palladium species, and a bis‐benzylated Pd(II) intermediate would be formed in our catalytic system. Atom economical processes such as benzylic CH activation, cascade reactions and chemoselective reactions in aqueous media have been developed.magnified image