N-benzyl-6-hydroxypyridine-2-carboxamide | 1033804-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-benzyl-6-hydroxypyridine-2-carboxamide
• 英文别名: N-benzyl-6-oxo-1H-pyridine-2-carboxamide
• CAS: 1033804-34-0
• 化学式: C₁₃H₁₂N₂O₂
• 分子量: 228.25
• InChiKey: XAFAJMLUMWEECP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-benzyl-2,3-dihydroxybenzamide 、 6-甲氧基吡啶-2-甲酸 生成 N-benzyl-6-hydroxypyridine-2-carboxamide
  参考文献：
  名称：

  Terephthalamate Compounds and Compositions, and Their Use as HIV Integrase Inhibitors

  摘要：

  本文描述了具有苯二甲酰胺结构特征的化合物。还描述了制备这样的化合物的方法，使用这样的化合物调节HIV整合酶活性的方法，以及包含这样的化合物的制药组合物和药物。还描述了使用这样的化合物、制药组合物和药物来治疗和/或预防和/或抑制和/或改善艾滋病或HIV感染的病理学和/或症状学的方法。

  公开号：

  US20100016379A1

文献信息

• SMALL MOLECULE COMPOUNDS AS BROAD-SPECTRUM INHIBITORS OF METALLO-BETA-LACTAMASES
  申请人：Song Yongcheng

  公开号：US20120329842A1

  公开（公告）日：2012-12-27

  The present invention concerns methods and/or compositions for treatment and/or prevention of bacterial infection wherein the bacteria has at least one metallo-β-lactamase. The bacteria are provided with an inhibitor of the metallo-β-lactamase, for example in conjunction with an antibiotic that targets the bacteria. The bacteria may be a drug-resistant strain or susceptible to becoming a drug-resistant strain. In specific embodiments, the bacteria is Pseudomonas or Acinetobacter spp.
• [EN] TEREPHTHALAMATE COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS HIV INTEGRASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS DE TÉRÉPHTALAMATE, ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE L'INTÉGRASE DU VIH
  申请人：IRM LLC

  公开号：WO2008073138A2

  公开（公告）日：2008-06-19

  [EN] Described herein are compounds having a terephthalamate structural feature. Also described herein, are methods of making such compounds, methods of using such compounds to modulate the activity of HIV integrase, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology of AIDS or infection with HIV.
  [FR] L'invention concerne des composés ayant une caractéristique structurale de téréphtalamate. L'invention concerne également des procédés de fabrication de tels composés, des procédés d'utilisation de tels composés pour moduler l'activité de l'intégrase du VIH, et des compositions pharmaceutiques et des médicaments comprenant de tels composés. L'invention concerne également des procédés d'utilisation de tels composés, des compositions pharmaceutiques et des médicaments pour traiter et/ou prévenir et/ou inhiber et/ou améliorer la pathologie et/ou la symptomatologie du SIDA ou d'une infection par le VIH.
• [EN] SMALL MOLECULE COMPOUNDS AS BROAD-SPECTRUM INHIBITORS OF METALLO-BETA-LACTAMASES<br/>[FR] COMPOSÉS À PETITES MOLÉCULES COMME INHIBITEURS À LARGE SPECTRE DE MÉTALLO-BÊTA-LACTAMASES
  申请人：BAYLOR COLLEGE MEDICINE

  公开号：WO2012088283A1

  公开（公告）日：2012-06-28

  The present invention concerns methods and/or compositions for treatment and/or prevention of bacterial infection wherein the bacteria has at least one metallo-P-lactamase. The bacteria are provided with an inhibitor of the metallo-P-lactamase, for example in conjunction with an antibiotic that targets the bacteria. The bacteria may be a drug-resistant strain or susceptible to becoming a drug-resistant strain. In specific embodiments, the bacteria is Pseudomonas or Acinetobacter spp.