4-([1,1‘-biphenyl]-3-yl)thiazol-2-amine | 900514-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-([1,1‘-biphenyl]-3-yl)thiazol-2-amine
• 英文别名: 4-([1,1'-Biphenyl]-3-yl)thiazol-2-amine；4-biphenyl-3-ylthiazol-2-ylamine；4-(3-Phenylphenyl)-1,3-thiazol-2-amine
• CAS: 900514-77-4
• 化学式: C₁₅H₁₂N₂S
• 分子量: 252.34
• InChiKey: OHHZIZWKEMJPFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-([1,1‘-biphenyl]-3-yl)thiazol-2-amine 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 18.08h， 以30%的产率得到15-methyl-8-nitro-N-[4-(3-phenylphenyl)-1,3-thiazol-2-yl]tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaene-15-carboxamide
  参考文献：
  名称：

  WO2006/76702

  摘要：

  公开号：

文献信息

• 4-SUBSTITUTED-2-THIAZOLE AMIDES AS ANTIVIRAL AGENTS
  申请人：Southern Research Institute

  公开号：US20200399264A1

  公开（公告）日：2020-12-24

  The present disclosure is concerned with benzoannulene compounds that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, chikungunya, Venezuelan equine encephalitis, Eastern equine encephalitis, Western equine encephalitis, dengue, West Nile, influenza, and zika, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制病毒感染的苯并环己烯化合物，以及利用这些化合物治疗病毒感染的方法，例如印度支那病毒、委内瑞拉马脑炎、东部马脑炎、西部马脑炎、登革热、西尼罗河病毒、流感和寨卡病毒。本摘要旨在作为特定领域搜索的扫描工具，并不意味着限制本发明。
• Modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
  申请人：Dhar Murali T.G.

  公开号：US20070179189A1

  公开（公告）日：2007-08-02

  A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or (II): including a stereoisomer thereof, a tautomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Q is selected from N, O, and S; Y is aryl or heteroaryl; Z is H, C 2-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, or alkoxy; and A, B, R, R a , R b , R c and R d are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  提供了一类新型的非类固醇化合物，其在治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病方面具有用处，包括肥胖症、糖尿病、炎症和免疫性疾病，并具有以下结构的式子(I)或(II)：包括其立体异构体、互变异构体、前药或药物可接受的盐，其中Q选择自N、O和S；Y为芳基或杂环芳基；Z为H、C2-6烷基、环烷基、杂环烷基、芳基、杂环芳基、卤素或烷氧基；A、B、R、Ra、Rb、Rc和Rd在此定义。还提供了包含该化合物的药物组合物和治疗肥胖、糖尿病和炎症或免疫相关疾病的方法。
• Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
  申请人：Chakravarty K. Prasun

  公开号：US20070060584A1

  公开（公告）日：2007-03-15

  Biaryl substituted thiazole, oxazole and imidazole compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment or prevention of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.

  双芳基取代噻唑、噁唑和咪唑化合物是钠通道阻滞剂，可用于治疗疼痛。制药组合物包括有效量的本化合物，单独或与一个或多个治疗活性化合物组合，并含有药用载体。治疗或预防急性疼痛、慢性疼痛、内脏疼痛、炎症性疼痛和神经病理性疼痛的方法包括单独或与一个或多个治疗活性化合物组合，给予本化合物的有效量。
• MODULATORS OF THE GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
  申请人：Dhar T.G. Murali

  公开号：US20100113532A1

  公开（公告）日：2010-05-06

  A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or (II): including a stereoisomer thereof, a tautomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof, where Q is selected from N, O, and S; Y is aryl or heteroaryl; Z is H, C 2-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, or alkoxy; and A, B, R, R a , R b , R c and R d are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  提供了一类新型非甾体化合物，其在治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病中有用，包括肥胖症、糖尿病、炎症和免疫性疾病，其结构为公式（I）或（II）：包括其立体异构体、互变异构体、前药或其药学上可接受的盐，其中Q从N、O和S中选择；Y为芳基或杂环芳基；Z为H、C2-6烷基、环烷基、杂环烷基、芳基、杂环芳基、卤素或烷氧基；A、B、R、Ra、Rb、Rc和Rd在此定义。还提供了包含该化合物的制药组合物和治疗肥胖症、糖尿病和炎症或免疫相关疾病的方法。
• SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES
  申请人：Masarykova univerzita

  公开号：EP3556756A1

  公开（公告）日：2019-10-23

  The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.

  本发明提供了结构式（1）所代表的化合物： 其中 R1、R2、R3、R4、R5、R6 如权利要求中定义。这些化合物是核酸酶的抑制剂，特别适用于增殖性疾病、神经退行性疾病和其他基因组不稳定性相关疾病的治疗和/或预防方法。