(R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid | 537706-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid
• 英文别名: (2R)-4,4-dimethyl-2-(2-morpholin-4-yl-2-oxoethyl)-5-phenylpentanoic acid
• CAS: 537706-86-8
• 化学式: C₁₉H₂₇NO₄
• 分子量: 333.428
• InChiKey: OWJVOLVNXKOQPW-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid 、 (S)-2-Amino-1-(3-phenyl-1,2,4-oxadiazol-5-yl)-butan-1-ol 生成 (r)-4,4-Dimethyl-2-(2-morpholin-4-yl-2-oxo-ethyl)-5-phenyl-pentanoic acid[1-(3-phenyl-1,2,4-oxadiazole-5-carbonyl)-propyl]-amide
  参考文献：
  名称：

  Compounds and compositions as cathepsin inhibitors

  摘要：

  本发明涉及新型的S型卡特普西酶抑制剂，其药用盐和N-氧化物，以及它们作为治疗剂的用途和制备方法。

  公开号：

  US07030116B2

文献信息

• Compounds and compositions as cathepsin inhibitors
  申请人：Aventis Pharmaceuticals Inc.

  公开号：US07030116B2

  公开（公告）日：2006-04-18

  The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及新型的S型卡特普西酶抑制剂，其药用盐和N-氧化物，以及它们作为治疗剂的用途和制备方法。
• MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS
  申请人：Aventis Pharmaceuticals, Inc.

  公开号：EP1515726A1

  公开（公告）日：2005-03-23
• US7030116B2
  申请人：——

  公开号：US7030116B2

  公开（公告）日：2006-04-18
• [EN] MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS<br/>[FR] DERIVES DE MORPHOLINE ET DE TETRAHYDROPYRANE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE CATHEPSINE
  申请人：AVENTIS PHARMA INC

  公开号：WO2004002491A1

  公开（公告）日：2004-01-08

  The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
• Novel compounds and compositions as cathepsin inhibitors
  申请人：——

  公开号：US20030105099A1

  公开（公告）日：2003-06-05

  The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.

  本发明涉及新型卡特普西林S抑制剂、其药学上可接受的盐和N-氧化物，它们作为治疗剂的用途以及它们的制备方法。