(R)-3,3'-bis(3,4,5-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethanol | 911701-85-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-3,3'-bis(3,4,5-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethanol
• 英文别名: [2-[2-(Hydroxymethyl)-5-methoxy-4,6-dimethyl-3-(3,4,5-trifluorophenyl)phenyl]-4-methoxy-3,5-dimethyl-6-(3,4,5-trifluorophenyl)phenyl]methanol
• CAS: 911701-85-4
• 化学式: C₃₂H₂₈F₆O₄
• 分子量: 590.562
• InChiKey: YUTWXCZLCIDURE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (R)-3,3'-bis(3,4,5-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethanol 在 三溴化磷 作用下， 以 环戊基甲醚 为溶剂， 反应 4.0h， 生成 3,3'-bis(3,4,5,-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethyl bromide 、 3,3'-bis(3,4,5,-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethyl bromide
  参考文献：
  名称：

  EP1870403

  摘要：

  公开号：
• 作为产物：
  描述：

  (S)-3,3'-bis(3,4,5-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxy diphenate dimethyl ester 在 lithium aluminium tetrahydride 、 盐酸 作用下， 以 环戊基甲醚 、 水 为溶剂， 反应 3.0h， 生成 (R)-3,3'-bis(3,4,5-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethanol 、 (R)-3,3'-bis(3,4,5-trifluorophenyl)-4,6,4',6'-tetramethyl-5,5'-dimethoxybiphenyl-2,2'-dimethanol
  参考文献：
  名称：

  EP1870403

  摘要：

  公开号：

文献信息

• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING -AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP1870403A1

  公开（公告）日：2007-12-26

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• Optically active quaternary ammonium salt having axial asymmetry and process for producing alpha-amino acid and derivative thereof with the same
  申请人：NAGASE & COMPANY, LTD.

  公开号：EP2484667A1

  公开（公告）日：2012-08-08

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.

  本发明提供了下式（I）的手性相转移催化剂： 化合物(I)可通过 2,2'-二亚甲基溴-1,1'-联苯衍生物与易得的仲胺反应制得，该衍生物可通过相对较少的步骤制得。
• OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME
  申请人：Maruoka Keiji

  公开号：US20090270614A1

  公开（公告）日：2009-10-29

  The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2′-dimethylene bromide-1,1′-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.
• US8614316B2
  申请人：——

  公开号：US8614316B2

  公开（公告）日：2013-12-24