N-(2,2-dimethylpropyl)-N-ethylcyclohexanamine | 1438857-81-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2,2-dimethylpropyl)-N-ethylcyclohexanamine
• CAS: 1438857-81-8
• 化学式: C₁₃H₂₇N
• 分子量: 197.364
• InChiKey: HEOWMXIETNTMQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-pivaloyl(ethyl)aniline 在 氢气 作用下， 以 乙二醇二甲醚 为溶剂， 160.0 ℃ 、3.0 MPa 条件下， 反应 20.0h， 生成 N-(2,2-dimethylpropyl)-N-ethylcyclohexanamine
  参考文献：
  名称：

  在温和条件下将酰胺催化加氢为胺

  摘要：

  在（不是很大）压力下：已开发出一种使用双金属Pd-Re催化剂将叔酰胺和仲酰胺氢化成胺的通用方法，具有优异的选择性。反应在低压和较低温度下进行。该方法为有机化学家提供了一种简单可靠的胺合成工具。

  DOI：

  10.1002/anie.201207803

文献信息

• SUBSTITUTED AZASPIRO DERIVATIVES
  申请人：Xu Yuelian

  公开号：US20080247964A1

  公开（公告）日：2008-10-09

  Substituted azaspiro derivatives of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

  提供了公式中的替代的azaspiro衍生物，其中变量如本文所述。这些化合物可以用于调节组织胺H3受体在体内或体外的配体结合，并在治疗人类、家养伴侣动物和家畜动物的各种中枢神经系统（CNS）和其他疾病方面特别有用。本文提供的化合物可以单独或与一个或多个其他CNS药剂联合使用，以增强其他CNS药剂的效果。提供了用于治疗这些疾病的药物组合物和方法，以及用于检测组织胺H3受体（例如，受体定位研究）的配体的方法。
• Substituted heteroaryl CB1 antagonists
  申请人：Yuan Jun

  公开号：US20070078135A1

  公开（公告）日：2007-04-05

  Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CB1 modulation in humans, domesticated companion animals and livestock animals, including appetite disorders, obesity and addictive disorders. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies and various in vitro assays.

  提供了公式I的化合物，其中变量如此处所述。这些化合物可用于在体内或体外调节CB1活性，并且在治疗对CB1调节敏感的人类、驯养的伴侣动物和家畜动物的食欲紊乱、肥胖和成瘾性疾病方面特别有用。提供了用于治疗此类疾病的制药组合物和方法，以及用于受体定位研究和各种体外测定的配体的使用方法。
• TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES AND RELATED ANALOGUES
  申请人：Xu Yuelian

  公开号：US20080051387A1

  公开（公告）日：2008-02-28

  Tetrahydropyrido[3,4-d]pyrimidines and related analogues are provided, of the formula: in which variables are as described herein, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are partially useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

  提供了Tetrahydropyrido[3,4-d]pyrimidines及其相关类似物，其化学式为：其中变量如本文所述，同时提供了其制备和使用的方法。这些化合物通常可用于调节体内或体外组绑定到组胺H3受体的配体，并在人类、家畜伴侣动物和家畜动物的多种疾病治疗中部分有用。提供了制药组合物和治疗方法，以及使用此类配体检测组胺H3受体的方法（例如，受体定位研究）。
• Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues
  申请人：Gao Yang

  公开号：US20070232591A1

  公开（公告）日：2007-10-04

  Piperazinyl oxoalkyl tetrahydroisoquinolines and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) and other disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).

  提供了式子中描述的Piperazinyl oxoalkyl tetrahydroisoquinolines和相关类似物，其中变量如此处所述。这些化合物可用于调节体内或体外的组胺H3受体的配体结合，并且在治疗人类、驯养伴侣动物和家畜动物的各种中枢神经系统（CNS）和其他疾病方面特别有用。此处提供的化合物可以单独或与一种或多种其他CNS药物联合使用，以增强其他CNS药物的效果。提供了用于治疗此类疾病的制药组合物和方法，以及用于检测组胺H3受体（例如受体定位研究）的配体的方法。
• 2-phenoxy pyrimidinone analogues
  申请人：Bakthavatchalam Rajagopal

  公开号：US20090069347A1

  公开（公告）日：2009-03-12

  2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

  本发明提供了2-苯氧基嘧啶酮类似物，其化学式如下：其中变量如本文所述。这些化合物是配体，可用于体内或体外调节特定受体活性，并在治疗与人类、家畜伴侣动物和家畜动物的病理性受体激活相关的疾病方面特别有用。还提供了制备这样的化合物的制药组合物和使用这样的化合物治疗这些疾病的方法，以及使用这样的配体进行受体定位研究的方法。