1,4-Dihydroxy-5-phenylpyridin-2-one | 1442693-41-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,4-Dihydroxy-5-phenylpyridin-2-one
• CAS: 1442693-41-5
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: PDSRZIHUKZYNSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R,5S,6R)-6-sec-butyl-tetrahydro-3,5-dimethylpyran-2-one 、 1,4-Dihydroxy-5-phenylpyridin-2-one 在 二异丁基氢化铝 、 2-氨基-4-氟吡啶 作用下， 以 正己烷 、 二氯甲烷 、 1,4-二氧六环 为溶剂， 反应 20.5h， 以77.778%的产率得到
  参考文献：
  名称：

  Concise Synthesis of Reduced Propionates by Stereoselective Reductions Combined with the Kobayashi Reaction

  摘要：

  A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukalyama aldol reaction and regio- and stereoselective reduction reactions. All Isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.

  DOI：

  10.1021/ol401406m

文献信息

• Concise Synthesis of Reduced Propionates by Stereoselective Reductions Combined with the Kobayashi Reaction
  作者：Tatsuya Nakamura、Mio Harachi、Takaaki Kano、Yuki Mukaeda、Seijiro Hosokawa

  DOI：10.1021/ol401406m

  日期：2013.6.21

  A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukalyama aldol reaction and regio- and stereoselective reduction reactions. All Isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.