2-(4-benzyloxy-3,5-dimethoxyphenyl)ethanol | 868732-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(4-benzyloxy-3,5-dimethoxyphenyl)ethanol
• 英文别名: 2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-ethanol；2-(3,5-dimethoxy-4-phenylmethoxyphenyl)ethanol
• CAS: 868732-20-1
• 化学式: C₁₇H₂₀O₄
• 分子量: 288.343
• InChiKey: XXRCJXSLALHPCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(4-benzyloxy-3,5-dimethoxyphenyl)ethanol 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 6.0h， 以55%的产率得到2-(4-(benzyloxy)-3,5-dimethoxyphenyl)acetaldehyde
  参考文献：
  名称：

  Contrast agents for myocardial perfusion imaging

  摘要：

  本公开涉及部分用于心肌灌注成像的化合物和方法，包括向患者注射一种对MC-1结合的化合物和成像基团构成的造影剂，并利用诊断成像对患者进行扫描。

  公开号：

  US20050244332A1
• 作为产物：
  描述：

  2,6-dibromo-4-(2-hydroxyethyl)phenol 在 potassium carbonate 、 copper(I) bromide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 3.5h， 生成 2-(4-benzyloxy-3,5-dimethoxyphenyl)ethanol
  参考文献：
  名称：

  Zheng, Cheng; Guo, Yibing; Meng, Ying, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013, vol. 52, # 5, p. 654 - 664

  摘要：

  DOI：

文献信息

• CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING
  申请人：Radeke Heike S.

  公开号：US20090104118A1

  公开（公告）日：2009-04-23

  The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.

  本公开涉及部分化合物和成像心肌灌注的方法，包括向患者注射一种对MC-1具有结合作用的化合物和成像基团构成的对比剂，并使用诊断成像对患者进行扫描。
• Contrast Agents for Myocardial Perfusion Imaging
  申请人：Lantheus Medical Imaging, Inc.

  公开号：EP2253333A2

  公开（公告）日：2010-11-24

  The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent which comprises a compound that binds MC-1, and an imaging moiety, and scanning the patient using diagnostic imaging.

  本公开内容部分涉及用于心肌灌注成像的化合物和方法，包括向患者施用造影剂，该造影剂由结合 MC-1 的化合物和成像分子组成，并使用诊断成像对患者进行扫描。
• Free radical scavenging and hepatoprotective effects of salidroside analogs on CCl4-induced cytotoxicity in LO2 cells
  作者：Yibing Guo、Cheng Zheng、Wen Xu、Yongxing Si、Sufeng Dou、Yumin Yang

  DOI：10.1007/s00044-012-0247-z

  日期：2013.5

  Salidroside, a phenylpropanoid glycoside isolated from a traditional Chinese medicinal plant Rhodiola rosea L. displays a broad spectrum of pharmacological properties. It has been found to play a hepatoprotective role in liver diseases through inhibiting apoptosis of hepatocytes and proliferation of hepatic stellate cells, decreasing serum aminotransferase, reversing hepatic fibrosis, and improving liver function. In this study as an ongoing study on the discovery and development of new hepatoprotective agents, about 12 novel glycosides were synthesized, and 2,2-diphenyl-1-picrylhydrazyl radical scavenge activity of each glycoside was evaluated. 2-(3,4,5-trihydroxyphenyl)ethyl beta-d-glucopyranoside (4g) and 2-(3,4,5-trihydroxyphenyl)ethyl beta-d-galactopyranoside (4h) exhibited significant activity prior to salidroside with an IC50 value of 38.05 and 35.85 mu M, respectively. The hepatoprotective effect of compounds 4g and 4h on CCl4-induced cytotoxicity in LO2 cells was assessed for further research.2-(3,4,5-Trihydroxyphenyl)ethyl beta-d-glucopyranoside (4g) and 2-(3,4,5-trihydroxyphenyl)ethyl beta-d-galactopyranoside (4h) exhibited significant hepatoprotective activity prior to salidroside.
• EP1740225A4
  申请人：——

  公开号：EP1740225A4

  公开（公告）日：2009-08-19
• US7485283B2
  申请人：——

  公开号：US7485283B2

  公开（公告）日：2009-02-03