2-diisopropylamino-ethyl hydrogen methylphosphonothioate | 959859-39-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-diisopropylamino-ethyl hydrogen methylphosphonothioate
• 英文别名: Diisopropylaminoethyl methyl phosphonothioic acid；N-[2-[hydroxy(methyl)phosphinothioyl]oxyethyl]-N-propan-2-ylpropan-2-amine
• CAS: 959859-39-3
• 化学式: C₉H₂₂NO₂PS
• 分子量: 239.319
• InChiKey: WWZJALUCZAGECX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  64.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-diisopropylamino-ethyl hydrogen methylphosphonothioate 、 碘甲烷 在 sodium carbonate 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 以2%的产率得到O-2-diisopropylamino-ethyl S-methyl methylphosphonothioate
  参考文献：
  名称：

  Novel methods for ester detoxication

  摘要：

  这项发明涉及一种用于解毒无机或有机酯类化合物，包括OP神经毒剂、可卡因及其类似物的方法。更具体地说，这项发明涉及通过开发一种更有效的水解酶用于治疗应激性神经毒性酯类化合物或其他酯基团。提供了合成的OP类似物的结构。这项发明还提供了一种诊断方法和用于检测生物和环境样本中的OP类毒剂的阵列生物传感器。

  公开号：

  US20070286846A1
• 作为产物：
  描述：

  1-[2-[di(propan-2-yl)amino]ethoxy-methylphosphinothioyl]oxy-N-methyl-1-phenylpropan-2-amine 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 、 水 为溶剂， 反应 18.0h， 以91%的产率得到2-diisopropylamino-ethyl hydrogen methylphosphonothioate
  参考文献：
  名称：

  Novel methods for ester detoxication

  摘要：

  这项发明涉及一种用于解毒无机或有机酯类化合物，包括OP神经毒剂、可卡因及其类似物的方法。更具体地说，这项发明涉及通过开发一种更有效的水解酶用于治疗应激性神经毒性酯类化合物或其他酯基团。提供了合成的OP类似物的结构。这项发明还提供了一种诊断方法和用于检测生物和环境样本中的OP类毒剂的阵列生物传感器。

  公开号：

  US20070286846A1

文献信息

• Corrosion inhibition in hydrothermal processing
  申请人：General Atomics

  公开号：US10688464B2

  公开（公告）日：2020-06-23

  The disclosed technology relates to methods of inhibiting corrosion in reaction chambers configured for hydrothermal reaction of feeds containing a heteroatom. An embodiment of such a method comprises providing a feed stream comprising a phosphorus-containing material, an alkali metal compound, water, and a corrosion-inhibitor. The embodiment additionally includes introducing the feed stream and oxidant into a reactor chamber and oxidizing the phosphorus-containing material at an oxidation temperature greater than about 374° C. and an oxidation pressure exceeding about 25 bar, wherein the reactor chamber has inner surfaces comprising a material that corrodes when in contact with a phosphorus compound within the reactor. The embodiment additionally includes selectively reacting the corrosion-inhibitor with phosphorus within the reactor, thereby precipitating in the reactor chamber a phosphorus-containing solid inorganic compound. The embodiment further includes forming in the reactor chamber an alkali salt melt and carrying away from the reactor chamber a mixture comprising the solid phosphorus-containing inorganic compound and the alkali salt melt.

  所公开的技术涉及在为含有杂原子的进料进行水热反应而配置的反应室中抑制腐蚀的方法。这种方法的一个实施方案包括提供包含含磷材料、碱金属化合物、水和缓蚀剂的料流。该实施方案还包括将料流和氧化剂引入反应器腔室，并在氧化温度高于约 374 摄氏度、氧化压力超过约 25 巴的条件下氧化含磷材料，其中反应器腔室的内表面包括与反应器内的磷化合物接触时会腐蚀的材料。该实施方案还包括在反应器内选择性地使缓蚀剂与磷反应，从而在反应器腔体内析出含磷固体无机化合物。本实施例还包括在反应器腔体内形成碱盐熔体，并将包含固体含磷无机化合物和碱盐熔体的混合物带离反应器腔体。
• METHODS FOR ESTER DETOXICATION
  申请人：Human Biomolecular Research Institute

  公开号：EP2035032A2

  公开（公告）日：2009-03-18
• Functionalized dendritic polymers for the capture and neutralization of biological and chemical agents
  申请人：Denkewicz P. Raymond

  公开号：US20070014754A1

  公开（公告）日：2007-01-18

  The present invention describes compositions and methods for sorbing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendritic polymers and N-Halamine functionalized dendritic polymers. Such dendrimers are useful for the capture and neutralization of biological and chemical warfare agents.
• FUNCTIONALIZED DENDRITIC POLYMERS FOR THE CAPTURE AND NEUTRALIZATION OF BIOLOGICAL AND CHEMICAL AGENTS
  申请人：Mahmud Khaled

  公开号：US20070071713A1

  公开（公告）日：2007-03-29

  The present invention describes compositions and methods for trapping/capturing and/or destroying dangerous substances such as chemical and biological warfare agents. The present invention relates to dendritic polymers, specifically, to quaternary ammonium functionalized dendritic polymers and N-Halamine functionalized dendritic polymers. Such dendrimers are useful for the capture and neutralization of biological and chemical warfare agents.
• CORROSION INHIBITION IN HYDROTHERMAL PROCESSING
  申请人：General Atomics

  公开号：US20180345241A1

  公开（公告）日：2018-12-06

  The disclosed technology relates to methods of inhibiting corrosion in reaction chambers configured for hydrothermal reaction of feeds containing a heteroatom. An embodiment of such a method comprises providing a feed stream comprising a phosphorus-containing material, an alkali metal compound, water, and a corrosion-inhibitor. The embodiment additionally includes introducing the feed stream and oxidant into a reactor chamber and oxidizing the phosphorus-containing material at an oxidation temperature greater than about 374° C. and an oxidation pressure exceeding about 25 bar, wherein the reactor chamber has inner surfaces comprising a material that corrodes when in contact with a phosphorus compound within the reactor. The embodiment additionally includes selectively reacting the corrosion-inhibitor with phosphorus within the reactor, thereby precipitating in the reactor chamber a phosphorus-containing solid inorganic compound. The embodiment further includes forming in the reactor chamber an alkali salt melt and carrying away from the reactor chamber a mixture comprising the solid phosphorus-containing inorganic compound and the alkali salt melt.