1-((3S,4R,5R)-3-(difluoromethyl)-4,5-dihydroxypiperidine-1-yl)pentane-1-one | 1293279-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-((3S,4R,5R)-3-(difluoromethyl)-4,5-dihydroxypiperidine-1-yl)pentane-1-one
• 英文别名: 1-[(3S,4R,5R)-3-(difluoromethyl)-4,5-dihydroxypiperidin-1-yl]pentan-1-one
• CAS: 1293279-74-9
• 化学式: C₁₁H₁₉F₂NO₃
• 分子量: 251.274
• InChiKey: YYULLGANQITQJB-QXFUBDJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-((3S,4R,5R)-3-(difluoromethyl)-4,5-dihydroxypiperidine-1-yl)pentane-1-one 、 、 戊酰氯 以the title compound was obtained as a white solid (0.26 g, 71%)的产率得到(3R,4R,5S)-5-(difluoromethyl)piperidine-3,4-diol hydrochloride
  参考文献：
  名称：

  NOVEL COMPOSITIONS FOR PREVENTING AND/OR TREATING DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM

  摘要：

  本发明提供了新型化合物，以及使用这些化合物的组合物和方法，用于预防和/或治疗中枢神经系统的退行性疾病。特别是，本发明提供了预防和/或治疗帕金森病的方法。

  公开号：

  US20110092541A1

文献信息

• NOVEL COMPOSITIONS FOR PREVENTING AND/OR TREATING LYSOSOMAL STORAGE DISORDERS
  申请人：Boyd Robert

  公开号：US20110091442A1

  公开（公告）日：2011-04-21

  The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.

  本发明提供了新型组合物以及预防和/或治疗溶酶体贮存障碍的方法。特别是，本发明提供了预防和/或治疗高加索氏病的方法。
• Method for Treating Alzheimer's Disease Using Pharmacological Chaperones To Increase The Activity of Gangliosidases
  申请人：Wustman Brandon

  公开号：US20120309788A1

  公开（公告）日：2012-12-06

  The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.

  本发明涉及一种治疗患有阿尔茨海默病的个体的方法，该方法使用药理伴侣增加参与神经节苷脂降解的神经节苷脂酶和/或唾液酸酶酶活性。
• Method for treating alzheimer's disease using pharmacological chaperones to increase the activity of gangliosidases
  申请人：Wustman Brandon

  公开号：US09044437B2

  公开（公告）日：2015-06-02

  The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.

  本发明涉及一种通过使用药理伴侣增加参与神经节苷脂降解的神经节苷脂酶和/或唾液酸酶酶活性来治疗患有阿尔茨海默病的个体的方法。
• Novel Compositions for Preventing and/or Treating Degenerative Disorders of the Central Nervous System
  申请人：AMICUS THERAPEUTICS, INC.

  公开号：US20140080871A1

  公开（公告）日：2014-03-20

  The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.

  本发明提供了一种新型化合物，以及使用该化合物的组合物和方法，用于预防和/或治疗中枢神经系统的退行性疾病。特别是，本发明提供了预防和/或治疗帕金森病的方法。
• Novel Compositions for Preventing and/or Treating Lysosomal Storage Disorders
  申请人：Amicus Therapeutics, Inc.

  公开号：US20140086896A1

  公开（公告）日：2014-03-27

  The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.

  本发明提供了新型组成物以及预防和/或治疗溶酶体贮存疾病的方法。特别是，本发明提供了预防和/或治疗高氏病的方法。