(1S,7S,10R)-6,10-dimethyl-11-oxatricyclo[5.4.0.0(1,10)]undec-5-en-2-one | 1236304-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (1S,7S,10R)-6,10-dimethyl-11-oxatricyclo[5.4.0.0(1,10)]undec-5-en-2-one
• 英文别名: (1S,7S,10R)-6,10-dimethyl-11-oxatricyclo[5.4.0.01,10]undec-5-en-2-one
• CAS: 1236304-45-2
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: SGLUOIYBNSKSEJ-MVWJERBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  29.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1S,7S,10R)-6,10-dimethyl-11-oxatricyclo[5.4.0.0(1,10)]undec-5-en-2-one 在 palladium 10% on activated carbon 、 氢气 作用下， 以 正己烷 为溶剂， 反应 1.0h， 以73%的产率得到(1S,6S,7S,10R)-6,10-dimethyl-11-oxatricyclo[5.4.0.0(1,10)]undecan-2-one
  参考文献：
  名称：

  Enantioselective formal total syntheses of Clavukerin A and isoclavukerin A via a ring-closing metathesis reaction

  摘要：

  Enantioselective formal total syntheses of the marine trisnorsesquiterpenes clavukerin A and isoclavukerin A, starting from (R)-limonene employing an RCM reaction as the key step, are described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.003
• 作为产物：
  描述：

  1-[(1S,2S,5R)-2-isopropenyl-5-methyl-6-oxabicyclo[3.1.0]hex-1-yl]pent-4-en-1-one 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 苯 为溶剂， 反应 1.0h， 以94%的产率得到(1S,7S,10R)-6,10-dimethyl-11-oxatricyclo[5.4.0.0(1,10)]undec-5-en-2-one
  参考文献：
  名称：

  Enantioselective formal total syntheses of Clavukerin A and isoclavukerin A via a ring-closing metathesis reaction

  摘要：

  Enantioselective formal total syntheses of the marine trisnorsesquiterpenes clavukerin A and isoclavukerin A, starting from (R)-limonene employing an RCM reaction as the key step, are described. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.003

文献信息

• Enantioselective formal total syntheses of Clavukerin A and isoclavukerin A via a ring-closing metathesis reaction
  作者：Adusumilli Srikrishna、Vijendra H. Pardeshi、Gedu Satyanarayana

  DOI：10.1016/j.tetasy.2010.04.003

  日期：2010.4

  Enantioselective formal total syntheses of the marine trisnorsesquiterpenes clavukerin A and isoclavukerin A, starting from (R)-limonene employing an RCM reaction as the key step, are described. (C) 2010 Elsevier Ltd. All rights reserved.