2-[9H-fluoren-9-ylmethoxycarbonyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)hexyl]amino]acetic acid | 1009309-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-[9H-fluoren-9-ylmethoxycarbonyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)hexyl]amino]acetic acid
• CAS: 1009309-45-8
• 化学式: C₃₈H₃₈N₂O₆
• 分子量: 618.73
• InChiKey: KMDAFYHDBNIGIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  46
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[9H-fluoren-9-ylmethoxycarbonyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)hexyl]amino]acetic acid 生成 2-(6-aminohexylamino)-N-[6-[[2-(6-aminohexylamino)acetyl]-(2-amino-2-oxoethyl)amino]hexyl]acetamide
  参考文献：
  名称：

  Peptoid dendrimers—microwave-assisted solid-phase synthesis and transfection agent evaluation

  摘要：

  Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.122
• 作为产物：
  描述：

  、 9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 16.0h， 以800 mg的产率得到2-[9H-fluoren-9-ylmethoxycarbonyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)hexyl]amino]acetic acid
  参考文献：
  名称：

  Peptoid dendrimers—microwave-assisted solid-phase synthesis and transfection agent evaluation

  摘要：

  Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.11.122