diethyl 2,2',6,6'-tetrafluorobiphenyl-3,3'-dicarboxylate | 1219103-72-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 2,2',6,6'-tetrafluorobiphenyl-3,3'-dicarboxylate
• 英文别名: Ethyl 3-(3-ethoxycarbonyl-2,6-difluorophenyl)-2,4-difluorobenzoate；ethyl 3-(3-ethoxycarbonyl-2,6-difluorophenyl)-2,4-difluorobenzoate
• CAS: 1219103-72-6
• 化学式: C₁₈H₁₄F₄O₄
• 分子量: 370.3
• InChiKey: TYMBQEZFAFPIKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,4-二氟苯甲酸乙酯 在 iron(III) chloride 、 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex 、 bis(2,2,6,6-tetramethylpiperidinyl)zinc, lithium chloride, magnesium chloride complex 、 氧气 作用下， 以 四氢呋喃 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 30.0h， 以70%的产率得到diethyl 2,2',6,6'-tetrafluorobiphenyl-3,3'-dicarboxylate
  参考文献：
  名称：

  Nickel, Manganese, Cobalt, and Iron-Catalyzed Deprotonative Arene Dimerization

  摘要：

  A number of first-row transition metal salts catalyze deprotonative dimerization of acidic arenes. Under the atmosphere of oxygen, nickel, manganese, cobalt, and Iron chlorides have been shown to dimerize five- and six-membered ring heterocycles as well as electron-poor arenes. Both tetramethylpiperidide and dicyclohexylamide bases can be employed; however, the former afford slightly higher yields.

  DOI：

  10.1021/ol902970z

文献信息

• Nickel, Manganese, Cobalt, and Iron-Catalyzed Deprotonative Arene Dimerization
  作者：Thanh Truong、Joseph Alvarado、Ly Dieu Tran、Olafs Daugulis

  DOI：10.1021/ol902970z

  日期：2010.3.19

  A number of first-row transition metal salts catalyze deprotonative dimerization of acidic arenes. Under the atmosphere of oxygen, nickel, manganese, cobalt, and Iron chlorides have been shown to dimerize five- and six-membered ring heterocycles as well as electron-poor arenes. Both tetramethylpiperidide and dicyclohexylamide bases can be employed; however, the former afford slightly higher yields.