2-Methyl-4-phenyl-2-imidazolin | 28438-04-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-4-phenyl-2-imidazolin
• 英文别名: 2-methyl-4-phenyl-4,5-dihydro-1(3)H-imidazole；2-Methyl-4-phenyl-4,5-dihydro-1(3)H-imidazol；2-methyl-5-phenyl-4,5-dihydro-1H-imidazole
• CAS: 28438-04-2
• 化学式: C₁₀H₁₂N₂
• 分子量: 160.219
• InChiKey: HGYSGRBMWKSVGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙腈 、 1-苯基-1,2-乙二胺 生成 2-Methyl-4-phenyl-2-imidazolin
  参考文献：
  名称：

  US2505247

  摘要：

  公开号：

文献信息

• Unprotected amine transfer performed by non-heme iron(<scp>ii</scp>) complexes
  作者：Alizée Boullé、Aminata Doumbia、Jean-Pierre Mahy、Frédéric Avenier

  DOI：10.1039/d2cc04992a

  日期：——

  Direct amination of C–H or CC bonds using unprotected amino groups is very challenging, especially with earth abundant metal ions. Here we show that a bioinspired iron(II) complex catalyses the double amination of its dangling benzyl branch in the presence of hydroxylamine derivatives as the unprotected amine donor and that the replacement of the benzyl branch by a methyl group also allows the aziridination

  使用未受保护的氨基直接胺化 C–H 或 C C 键非常具有挑战性，尤其是对于地球上丰富的金属离子。在这里，我们表明，在羟胺衍生物作为未保护的胺供体存在的情况下，受生物启发的铁 ( II ) 络合物催化其悬挂的苄基支链的双胺化，并且用甲基取代苄基支链也可以使苯乙烯氮丙啶化。
• [EN] MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING SHP2<br/>[FR] FABRICATION DE COMPOSÉS ET DE COMPOSITIONS POUR INHIBER SHP2
  申请人：NOVARTIS AG

  公开号：WO2022007502A1

  公开（公告）日：2022-01-13

  Provided herein is a method for the manufacture of a compound of Formula (I) or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula (II) with a compound of the formula (III) according to the following reaction scheme: wherein LG, A, n, m and p are as defined herein, said manufacture including the manufacture and use of a compound of the formula (VI): wherein R1 is a secondary amino protecting group and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.