(E)-1,3-benzodioxol-5-ylmethylidenehydrazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (E)-1,3-benzodioxol-5-ylmethylidenehydrazine
• 化学式: C₈H₈N₂O₂
• 分子量: 164.16
• InChiKey: PTCPMTHNSHEWEO-ONNFQVAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-1,3-benzodioxol-5-ylmethylidenehydrazine 生成 3,4-(亚甲二氧基)甲苯
  参考文献：
  名称：

  SANCHEZ-VIESCA F.; GOMEZ MA. R., REV. LATINOAMER. QUIM, 1974, 5, NO 4, 215-219

  摘要：

  DOI：
• 作为产物：
  描述：

  胡椒醛 、 肼 生成 (E)-1,3-benzodioxol-5-ylmethylidenehydrazine
  参考文献：
  名称：

  SANCHEZ-VIESCA F.; GOMEZ MA. R., REV. LATINOAMER. QUIM, 1974, 5, NO 4, 215-219

  摘要：

  DOI：

文献信息

• Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof
  申请人：——

  公开号：US20020128292A1

  公开（公告）日：2002-09-12

  The present invention is directed to substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs thereof, represented by the general Formula I: 1 wherein X, Ar 1 , R 2 -R 6 and R 12 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. The compounds of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

  本发明涉及取代的吲哚-2-羧酸亚苄基肼及其类似物，其由通式I表示： 1 其中X，Ar 1 ，R 2 -R 6 和R 12 的定义如本文中所述。本发明还涉及发现具有I式的化合物是半胱天冬酶的激活剂和凋亡的诱导剂。本发明的化合物可用于诱导在异常细胞不受控制的生长和扩散发生的多种临床状况中的细胞死亡。
• YONEDA FUMIO; NOGUCHI MITSUKO; NODA MITSUE; NITTA YOSHIHIRO, CHEM. AND PHARM. BULL., 1078, 62, NO 10, 3154-3160
  作者：YONEDA FUMIO、 NOGUCHI MITSUKO、 NODA MITSUE、 NITTA YOSHIHIRO

  DOI：——

  日期：——
• POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC BODY
  申请人：ZEON CORPORATION

  公开号：US20140107247A1

  公开（公告）日：2014-04-17

  The invention provides a polymerizable compound represented by formula (I), a polymerizable composition, and a polymer that have a practical low melting point, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article. In the formula: Y 1 -Y 6 represent a single bond, —O—, —O—C(═O)—, —C(═O)—O—, or the like; G 1 and G 2 represent a bivalent aliphatic group, or the like, of C1-20; Z 1 and Z 2 represent a C2-10 alkenyl group or the like; A x represents a C2-30 organic group, or the like, having at least one aromatic ring selected from an aromatic hydrocarbon ring and a hetero-aromatic ring; A y represents a hydrogen atom, a C1-6 alkyl group, or a C2-30 organic group, or the like, having at least one aromatic ring selected from an aromatic hydrocarbon ring and a hetero-aromatic ring; A 1 represents a trivalent aromatic group or the like; A 2 and A 3 represent a bivalent aromatic group or the like; Q 1 represents a hydrogen atom, a C1-6 alkyl group, or the like. A x and A y may form a ring together.
• US6747052B2
  申请人：——

  公开号：US6747052B2

  公开（公告）日：2004-06-08
• US9234056B2
  申请人：——

  公开号：US9234056B2

  公开（公告）日：2016-01-12