1-(4-bromopyridin-2-yl)cyclobutane-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(4-bromopyridin-2-yl)cyclobutane-1-carboxylic acid
• 英文别名: 1-(4-Bromopyridin-2-yl)cyclobutane-1-carboxylic acid
• 化学式: C₁₀H₁₀BrNO₂
• 分子量: 256.099
• InChiKey: FRGFIMUWRLSCDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-bromopyridin-2-yl)cyclobutane-1-carboxylic acid 以 甲苯 为溶剂， 以620 mg的产率得到2-环丁基4-溴-吡啶
  参考文献：
  名称：

  [EN] NOVEL SUBSTITUTED SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY
  [FR] NOUVEAUX COMPOSÉS DE SULFONYLURÉE SUBSTITUÉS EN TANT QU'INHIBITEURS DE L'ACTIVITÉ DE L'INTERLEUKINE-1

  摘要：

  This application relates to novel substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.

  公开号：

  WO2023056264A1
• 作为产物：
  描述：

  tert-butyl 1-(4-bromopyridin-2-yl)cyclobutane-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 1-(4-bromopyridin-2-yl)cyclobutane-1-carboxylic acid
  参考文献：
  名称：

  [EN] NOVEL SUBSTITUTED SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY
  [FR] NOUVEAUX COMPOSÉS DE SULFONYLURÉE SUBSTITUÉS EN TANT QU'INHIBITEURS DE L'ACTIVITÉ DE L'INTERLEUKINE-1

  摘要：

  This application relates to novel substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.

  公开号：

  WO2023056264A1

文献信息

• [EN] NOVEL SUBSTITUTED SULFONYLUREA COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY<br/>[FR] NOUVEAUX COMPOSÉS DE SULFONYLURÉE SUBSTITUÉS EN TANT QU'INHIBITEURS DE L'ACTIVITÉ DE L'INTERLEUKINE-1
  申请人：[en]ZHANG, Hongjian

  公开号：WO2023056264A1

  公开（公告）日：2023-04-06

  This application relates to novel substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.