1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine;hydrochloride
• 化学式: C15H14Cl3N5
• 分子量: 370.7
• InChiKey: LTWIBTYLSRDGHP-HCURTGQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.65
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2-bis[(E)-(4-chlorophenyl)methylideneamino]guanidine;hydrochloride 、 、 、 、 1,2-丙二醇 在 水 作用下， 以2.3 ml of said composition in 1 L of water yielded a concentration of 30 mg of Robenidine/ 1 L of water的产率得到robenidine
  参考文献：
  名称：

  Water-soluble composition comprising a robenidine salt

  摘要：

  公开了一种水溶性组合物，包括1,3-双[(对氯苯甲亚啉)-氨基]-鸟氨酸盐（称为Robenidine）,特别是盐酸盐。该组合物还包括适当的水溶性有机溶剂和适当的水溶性增溶剂；所述溶剂和增溶剂与彼此相混。还公开了包含上述组合物的水溶性溶液以及使用该水溶液治疗感染鸟球虫病的动物的方法。

  公开号：

  US03954996A1

文献信息

• Process for formulating a medicated animal feed premix
  申请人：ELI LILLY AND COMPANY

  公开号：EP0060680A1

  公开（公告）日：1982-09-22

  A process of formulating a medicated animal feed premix comprising a synthetic drug, carrier and binder, for the purpose of reducing carryover of the synthetic drug to subsequent lots of animal feed processed in the feed mill.

  一种由合成药物、载体和粘合剂组成的药物动物饲料预混料的配制工艺，目的是减少合成药物在饲料厂加工的后续批次动物饲料中的残留。
• APPLICATION OF CINNAMALDEHYDE AND/OR ALLANTOIN TO REPLACE HIGH ZINC AMOUNTS IN SUCKLING PIGLET FEED, FEED ADDITIVE OR ADDITIVE PREMIX, AND FEED
  申请人：Hunan Jingtian Technology Industry Co., Ltd.

  公开号：EP3804529A1

  公开（公告）日：2021-04-14

  Provided is an application of cinnamaldehyde and/or allantoin to partially replace or fully replace high zinc amounts in suckling piglet feed. Also provided are a feed additive or additive premix which uses cinnamaldehyde and/or allantoin to partially replace or fully replace high zinc amounts, and a suckling piglet feed which uses the feed additive or additive premix. The application of cinnamaldehyde and/or allantoin, the feed additive or additive premix and the feed reduce or remove the use of high zinc amounts in feed, and also have the effects of resisting diarrhea and promoting pig growth and development.

  提供了一种应用肉桂醛和/或尿囊素部分替代或完全替代乳仔猪饲料中高锌含量的方法。还提供了一种使用肉桂醛和/或尿囊素部分或全部替代高锌的饲料添加剂或添加剂预混料，以及一种使用该饲料添加剂或添加剂预混料的乳仔猪饲料。肉桂醛和/或尿囊素、饲料添加剂或添加剂预混料和饲料的应用减少或消除了饲料中高锌量的使用，还具有抗腹泻和促进猪生长发育的效果。
• Ultra high resolution mass spectrometry and methods of using the same
  申请人：MARS, INCORPORATED

  公开号：US10627407B2

  公开（公告）日：2020-04-21

  The presently disclosed subject matter provides methods for analyzing complex mixtures with ultra high resolution mass spectrometry. In particular, the presently disclosed subject matter provides methods for identifying and monitoring the presence of a compound within a complex mixture. In certain embodiments, the method includes providing a sample of the complex mixture; performing mass spectrometry on the sample of the complex mixture to obtain a mass spectrum; and identifying one or more peaks from the mass spectrum corresponding to the compound. In certain embodiments, the sample is obtained during production of the complex mixture, e.g., a pet food product. In certain embodiments, the sample is prepared by a single alcohol/water extraction step.

  本公开主题提供了利用超高分辨率质谱分析复杂混合物的方法。特别是，本公开主题提供了用于识别和监测复杂混合物中存在的化合物的方法。在某些实施例中，该方法包括提供复杂混合物的样品；对复杂混合物的样品进行质谱分析以获得质谱；以及从质谱中识别出对应于化合物的一个或多个峰。在某些实施例中，样品是在生产复合混合物（例如宠物食品）的过程中获得的。在某些实施方案中，样品是通过单一的醇/水萃取步骤制备的。
• Process for the preparation of robenidine and salts thereof
  申请人：——

  公开号：US20020123649A1

  公开（公告）日：2002-09-05

  The invention relates to a novel method for producing robenidine and salts thereof of the general formula 1 wherein X denotes a halogen atom. The method uses hydrazine hydrate and a cyano compound as the starting materials, and the starting materials are first reacted in a C 1-4 alcohol or a C 1-4 alcohoVwater mixture as solvent or in an aprotic organic solvent, to produce a diaminoguanidine of the general formula 2 wherein Y denotes a halogen atom or tosyl. This diaminoguanidine is then converted directly, without isolation, by reacting with a p-halobenzaldehyde of the general formula 3 in a C 1-4 alcohol or a C 1-4 alcohol/water mixture as solvent or in a mixture of water and an aprotic polar organic solvent to produce the robenidine and salts thereof of general formula I.

  本发明涉及一种生产通式为 1 的罗贝尼定及其盐类的新方法。 1 其中 X 表示卤素原子。该方法使用水合肼和氰基化合物作为起始原料，起始原料首先在 C 1-4 醇或 C 1-4 醇水混合物为溶剂或在无相有机溶剂中反应，生成通式为 2 其中 Y 表示卤素原子或甲苯基。然后不经分离，通过与通式 3 的对卤代苯甲醛反应，直接转化这种二氨基胍。 3 在 C 1-4 醇或 C 1-4 醇/水混合物作为溶剂，或在水和钝极性有机溶剂的混合物中，制得通式 I 的罗宾苷及其盐类。
• METHODS FOR TREATING PROTOZOAN INFECTIONS
  申请人：Neoculi Pty Ltd

  公开号：EP3188722A1

  公开（公告）日：2017-07-12