2-carboxybenzaldehydebenzoylhydrazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-carboxybenzaldehydebenzoylhydrazone
• 英文别名: 2-{(E)-[2-(phenylcarbonyl)hydrazinylidene]methyl}benzoic acid；2-[(E)-(benzoylhydrazinylidene)methyl]benzoic acid
• 化学式: C₁₅H₁₂N₂O₃
• 分子量: 268.272
• InChiKey: WMGNXSHCBFOLDJ-MHWRWJLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  lanthanum(III) nitrate hexahydrate 、 2-carboxybenzaldehydebenzoylhydrazone 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Crystal structure, antitumor activities and DNA-binding properties of the La(III) complex with Phthalazin-1(2H)-one prepared by a novel route

  摘要：

  Phthalazin-1(2H)-one was prepared by a novel route. The La(III)-complex of phthalazin-1(2H)-one, [La(NO3)(3)center dot 4H(2)O center dot C8H7-N2O]center dot H2O, was synthesized and characterized on the basis of elemental analysis, thermal analyses (TG/DTA) and X-ray crystallography. In the complex, the coordination number of the La(III) ion is eleven. The interaction of the ligand and its complex with calf thymus DNA was investigated by spectrophotometric methods and viscosity measurements, respectively. Experimental results indicated that phthalazin-1 (2H)-one and the complex can bind to DNA by intercalation modes, but the binding affinity of La(III)complex is higher than that of the ligand. Comparative antitumor activities of La(III)-complex was investigated by HL-60 and A-549. IC50 = 2.6 x 10(-8), 3.3 x 10(-5) mg/mL are given. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2005.07.046