N-propyl-4-iodobenzenesulphonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-propyl-4-iodobenzenesulphonamide
• 英文别名: 4-iodo-N-propylbenzenesulfonamide
• 化学式: C₉H₁₂INO₂S
• mdl: MFCD07424767
• 分子量: 325.17
• InChiKey: KGYDARINJYFOEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-propyl-4-iodobenzenesulphonamide 、 三乙基硅烷 在 N-甲基吡咯烷酮 、 platinum(IV) oxide 、 sodium acetate 作用下， 反应 1.0h， 以68%的产率得到N-propyl-4-triethylsilanyl-benzenesulfonamide
  参考文献：
  名称：

  Platinum Oxide Catalyzed Silylation of Aryl Halides with Triethylsilane:  An Efficient Synthetic Route to Functionalized Aryltriethylsilanes

  摘要：

  The first platinum-catalyzed selective silylation of aryl halides including aryl iodides and bromides having an electron-withdrawing group is described. The reaction takes place rapidly in NMP with triethylsilane as a silicon source and sodium acetate to provide functionalized aryltriethylsilanes in moderate to good yields. Heteroaromatic halides also were found to be readily silylated with triethylsilane. The procedure is chemoselective and tolerates a wide variety of functional groups.

  DOI：

  10.1021/ol052996u

文献信息

• [EN] SMALL MOLECULE AGONISTS OF MUCOLIPIN 1 AND USES THEREOF<br/>[FR] PETITES MOLÉCULES AGONISTES DE LA MUCOLIPINE 1 ET LEURS UTILISATIONS
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2021041866A1

  公开（公告）日：2021-03-04

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a phenyl-sulfonic amide (or similar) structure which function as agonists of mucolipin 1 (ML1), and their use as therapeutics for the treatment of Duchenne muscular dystrophy (DMD) and related disorders.

  这项发明属于药物化学领域。特别是，该发明涉及一类新的小分子，具有苯磺酰胺（或类似）结构，作为肌球脂蛋白1（ML1）的激动剂，以及它们作为治疗杜氏肌肉萎缩症（DMD）和相关疾病的疗法的用途。
• IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION
  申请人：AstraZeneca AB

  公开号：EP1351958B1

  公开（公告）日：2004-06-16
• Platinum Oxide Catalyzed Silylation of Aryl Halides with Triethylsilane:  An Efficient Synthetic Route to Functionalized Aryltriethylsilanes
  作者：Abdallah Hamze、Olivier Provot、Mouâd Alami、Jean-Daniel Brion

  DOI：10.1021/ol052996u

  日期：2006.3.2

  The first platinum-catalyzed selective silylation of aryl halides including aryl iodides and bromides having an electron-withdrawing group is described. The reaction takes place rapidly in NMP with triethylsilane as a silicon source and sodium acetate to provide functionalized aryltriethylsilanes in moderate to good yields. Heteroaromatic halides also were found to be readily silylated with triethylsilane. The procedure is chemoselective and tolerates a wide variety of functional groups.