(4-bromo-2-fluorophenyl)(2,2-diethoxyethyl)sulfane

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (4-bromo-2-fluorophenyl)(2,2-diethoxyethyl)sulfane
• 英文别名: 4-Bromo-1-(2,2-diethoxyethylsulfanyl)-2-fluorobenzene；4-bromo-1-(2,2-diethoxyethylsulfanyl)-2-fluorobenzene
• 化学式: C₁₂H₁₆BrFO₂S
• 分子量: 323.226
• InChiKey: BSFGGBSBLMFZFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (4-bromo-2-fluorophenyl)(2,2-diethoxyethyl)sulfane 在 polyphosphoric acid 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以18.7%的产率得到5-bromo-7-fluorobenzo[b]thiophene
  参考文献：
  名称：

  SUBSTITUTED BENZOTHIOPHENYL DERIVATIVES AS GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES

  摘要：

  揭示了一种通过调节GPR40受体来治疗受影响疾病的化合物、组合物和方法。这些化合物由以下式（I）表示： 其中U1、U2、U3、R1、R2、Z和W在此处定义。

  公开号：

  US20170291908A1

文献信息

• Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes
  申请人：Janssen Pharmaceutica NV

  公开号：US10106553B2

  公开（公告）日：2018-10-23

  Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein U1, U2, U3, R1, R2, Z, and W are defined herein.

  公开了用于治疗受 GPR40 受体调节影响的疾病的化合物、组合物和方法。此类化合物由如下式（I）表示： 其中 U1、U2、U3、R1、R2、Z 和 W 在此定义。
• 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-2(HETEROCYCLIC) PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES
  申请人：Dow AgroSciences LLC

  公开号：EP2970187A1

  公开（公告）日：2016-01-20
• [EN] 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-2(HETEROCYCLIC) PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES<br/>[FR] 4-AMINO-6-(HÉTÉROCYCLE)PICOLINATES ET 6-AMINO-2-2(HÉTÉROCYCLE) PYRIMIDINE-4-CARBOXYLATES ET LEUR UTILISATION COMME HERBICIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2014151005A1

  公开（公告）日：2014-09-25

  4-Amino-6-(heterocyclic )picolinic acids, 6-amino-2-(heterocyclic )pyrimidine-4-carboxylates, and derivatives thereof are provided. Also provided are herbicidal compositions including these compounds, as well as methods of using thereof as herbicides. The occurrence of undesirable vegetation, e.g., weeds, is a constant problem facing famers in crops, pasture, and other settings. Weeds compete with crops and negatively impact crop yield. The use of chemical herbicides is an important tool in controlling undesirable vegetation.
• [EN] SUBSTITUTED BENZOTHIOPHENYL DERIVATIVES AS GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES<br/>[FR] DÉRIVÉS DE BENZOTHIOPHÉNYLE SUBSTITUÉS UTILISÉS EN TANT QU'AGONISTES DE GPR40 POUR LE TRAITEMENT DU DIABÈTE DE TYPE II
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2017180571A1

  公开（公告）日：2017-10-19

  Disclosed are substituted benzothiophenyl derivatives, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor such as Type II diabetes mellitus. Such compounds are represented by Formula (I) as follows: