(2-{Hydroxy-[3-octadecanoyloxy-2-((Z)-octadec-9-enoyloxy)-propoxy]-phosphoryloxy}-ethyl)-trimethyl-ammonium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: (2-{Hydroxy-[3-octadecanoyloxy-2-((Z)-octadec-9-enoyloxy)-propoxy]-phosphoryloxy}-ethyl)-trimethyl-ammonium
• 英文别名: 1-Octadecanoyl-2-[cis-9-octadecenoyl]-SN-glycero-3-phosphocholine；2-[hydroxy-[3-octadecanoyloxy-2-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxyethyl-trimethylazanium
• 化学式: C₄₄H₈₇NO₈P
• 分子量: 789.15
• InChiKey: ATHVAWFAEPLPPQ-LNVKXUELSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  14.8
• 重原子数：
  54
• 可旋转键数：
  43
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  L-α-Dioleoyl-lecithin 在 铂 氢气 作用下， 以 乙醇 为溶剂， 生成 (2-{Hydroxy-[3-octadecanoyloxy-2-((Z)-octadec-9-enoyloxy)-propoxy]-phosphoryloxy}-ethyl)-trimethyl-ammonium
  参考文献：
  名称：

  de Haas,G.H.; van Deenen,L.L.M., Tetrahedron Letters, 1960, # 22, p. 7 - 9

  摘要：

  DOI：

文献信息

• Particles comprising surfactant protein B and one or more lipids
  申请人：Universiteit Gent

  公开号：US11213573B2

  公开（公告）日：2022-01-04

  The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.

  本发明尤其涉及微型和纳米颗粒领域，特别是涂层纳米颗粒。本发明的涂层尤其包括表面活性剂蛋白 B（SP-B）和一种或多种脂质。本发明还涉及此类包衣颗粒和包含它们的组合物，可用作药物，特别是用于治疗各种疾病。此外，本发明还提供了本发明组合物的用途，可将一种或多种药剂（如小界面 RNA（siRNA）分子）递送至靶组织或细胞。
• IMPROVED PROMOTERS AND COMPOSITIONS
  申请人：Oxford University Innovation Limited

  公开号：EP3423579A1

  公开（公告）日：2019-01-09
• INJECTABLE POLYMER-LIPID BLEND FOR LOCALIZED DRUG DELIVERY
  申请人：ALLEN Christine

  公开号：US20080311223A1

  公开（公告）日：2008-12-18

  An injectable polymer-lipid blend is provided as a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery.
• INJECTABLE POLYMER-LIPID BLEND
  申请人：ALLEN Christine

  公开号：US20090324741A1

  公开（公告）日：2009-12-31

  An injectable polymer-lipid blend is provided. The blend may provide a localized drug delivery system for a pharmaceutically active agent. The blend may be prepared from a chitosan-based material, fatty acid and phospholipid. The chitosan-based material may be a water soluble chitosan derivative. The fatty acid may be a fatty acid or a fatty aldehyde, such as laurinaldehyde, having an acyl chain length of C8-C16. The rheological properties of the blend relates to the ratio of the components and to the acyl chain length of the fatty acid. The injectable system is well suited for the delayed release of pharmaceutically active agents in the treatment of cancer and other diseases requiring localized drug delivery.
• PARTICLES COMPRISING SURFACTANT PROTEIN B AND ONE OR MORE LIPIDS
  申请人：UNIVERSITEIT GENT

  公开号：US20200197496A1

  公开（公告）日：2020-06-25

  The present invention in particular relates to the field of micro- and nanoparticles, more in particular to coated nanoparticles. The coatings of the present invention in particular comprise surfactant protein B (SP-B) and one or more lipids. The invention further relates to such coated particles and compositions comprising them for use as a medicament, in particular for use in the treatment of various disorders. Furthermore, the invention provides the use of the compositions of the current invention for delivering one or more agents, such as small interfacing RNA (siRNA) molecules, to the target tissue or cells.