6-(4-Fluoro-phenylsulfanyl)-5-methoxy-2-methyl-benzoselenazole-4,7-dione

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-(4-Fluoro-phenylsulfanyl)-5-methoxy-2-methyl-benzoselenazole-4,7-dione
• 英文别名: 6-(4-Fluorophenyl)sulfanyl-5-methoxy-2-methyl-1,3-benzoselenazole-4,7-dione
• 化学式: C₁₅H₁₀FNO₃SSe
• 分子量: 382.274
• InChiKey: CTYVHVWSNFXECC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  81.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对氟苯硫酚 、 5-Methoxy-2-methyl-benzoselenazole-4,7-dione 以 乙醇 为溶剂， 生成 6-(4-Fluoro-phenylsulfanyl)-5-methoxy-2-methyl-benzoselenazole-4,7-dione
  参考文献：
  名称：

  Synthesis and antifungal activity of noble 5-arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles

  摘要：

  5-Arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles 4 and 5 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-4,7-dioxobenzoselenazoles 4 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzoselenazoles 5. The results suggest that 5-arylamino-4,7-dioxobenzoselenazoles 4 would be potent antifungal agents. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.027

文献信息

• Synthesis and antifungal activity of noble 5-arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles
  作者：Chung-Kyu Ryu、Ja-Young Han、Ok-Jai Jung、Su-Kyung Lee、Jung Yoon Lee、Seong Hee Jeong

  DOI：10.1016/j.bmcl.2004.11.027

  日期：2005.2

  5-Arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles 4 and 5 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 5-Arylamino-4,7-dioxobenzoselenazoles 4 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzoselenazoles 5. The results suggest that 5-arylamino-4,7-dioxobenzoselenazoles 4 would be potent antifungal agents. (C) 2004 Elsevier Ltd. All rights reserved.