2-(1,3-Benzodioxol-5-yl)piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-(1,3-Benzodioxol-5-yl)piperidine
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.25
• InChiKey: UAGVRNQRAJIACI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(1,3-Benzodioxol-5-yl)piperidine 、 potassium carbonate 、 碘化钾 、 1-Butyl-4-chloro-5-chloromethyl-2-(2,6-dimethyl-phenyl)-1H-imidazole 在 silica gel 、 乙酸乙酯 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以to provide the title product 10 as a white solid的产率得到2-Benzo[1,3]dioxol-5-yl-1-[3-butyl-5-chloro-2-(2,6-dimethyl-phenyl)-3H-imidazol-4-ylmethyl]-piperidine
  参考文献：
  名称：

  Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators

  摘要：

  提供公式（I）的（杂环烷基）甲基唑衍生物：公式I其中A为氧、硫或NR; J和K和每个L独立地为氧、硫、NH或CH2; 其余变量在此定义。这些化合物是C5a受体的调节剂，且优选具有高亲和力并在C5a受体上表现为中性拮抗剂或反向激动剂活性。本文还提供了包含这些化合物的药物组合物，以及使用这些化合物治疗多种炎症和免疫系统疾病的方法。

  公开号：

  US20060154917A1

文献信息

• [EN] SUBSTITUTED (HETEROCYCLOALKYL)METHYL AZOLE DERIVATIVES AS C5A RECEPTOR MODULATORS<br/>[FR] DERIVES (HETEROCYCLOALKYL)METHYLE SUBSTITUES DE TYPE AZOLE UTILISES COMME MODULATEURS DES RECEPTEURS C5A
  申请人：NEUROGEN CORP

  公开号：WO2005007087A2

  公开（公告）日：2005-01-27

  (Heterocycloalkyl)methyl azole derivatives of Formula (I) are provided: Formula I wherein A is oxygen, sulfur, or NR; J and K and each L are independently oxygen, sulfur, NH, or CH2; and the remaining variables are defined herein. Such compounds are modulators of C5a receptors, and preferably bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. Also provided herein are pharmaceutical compositions comprising such compounds, as well as methods for using such compounds in treating a variety of inflammatory and immune system disorders.
• Substituted (heterocycloalkyl)methyl azole derivatives as c5a receptor modulators
  申请人：Zhang Suoming

  公开号：US20060154917A1

  公开（公告）日：2006-07-13

  (Heterocycloalkyl)methyl azole derivatives of Formula (I) are provided: Formula I wherein A is oxygen, sulfur, or NR; J and K and each L are independently oxygen, sulfur, NH, or CH 2 ; and the remaining variables are defined herein. Such compounds are modulators of C5a receptors, and preferably bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. Also provided herein are pharmaceutical compositions comprising such compounds, as well as methods for using such compounds in treating a variety of inflammatory and immune system disorders.

  提供公式（I）的（杂环烷基）甲基唑衍生物：公式I其中A为氧、硫或NR; J和K和每个L独立地为氧、硫、NH或CH2; 其余变量在此定义。这些化合物是C5a受体的调节剂，且优选具有高亲和力并在C5a受体上表现为中性拮抗剂或反向激动剂活性。本文还提供了包含这些化合物的药物组合物，以及使用这些化合物治疗多种炎症和免疫系统疾病的方法。