diethyl 4-(2,5-dimethoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: diethyl 4-(2,5-dimethoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate
• 英文别名: Diethyl 4-(2,5-dimethoxyphenyl)-2,6-dimethylpyridine-3,5-dicarboxylate
• 化学式: C₂₁H₂₅NO₆
• 分子量: 387.433
• InChiKey: ZQPALBFPGUUIGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  84
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  diethyl 4-(2,5-dimethoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 以 氯仿 为溶剂， 反应 14.0h， 生成 diethyl 4-(2,5-dimethoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylate
  参考文献：
  名称：

  1,4-二氢吡啶的固态光化学。

  摘要：

  已经研究了固态的一些1,4-二氢吡啶的光化学行为。尽管在溶液相中辐射1，4-二氢吡啶时，已经观察到它们的光氧化和吡啶衍生物的形成，但是以固态辐射这些化合物降低了它们的光敏性。在许多情况下，仅以非常低的产率观察到光氧化。

  DOI：

  10.1016/j.bmcl.2005.05.026

文献信息

• Aromatization of 1,4-dihydropyridines in the presence of methanesulfonic acid/NaNO₂/wet SiO₂under both heterogeneous and solvent free conditions
  作者：Khodabakhsh Niknam、Seyed Mehdi Razavian、Mohammah Ali Zolfigol、Iraj Mohammahpoor-Baltork

  DOI：10.1002/jhet.5570430131

  日期：2006.1

  A combination of methanesulfonic acid and sodium nitrite in the presence of wet SiO2 was used as an effective oxidizing agent for the oxidation of 1,4-dihydropyridines to the corresponding pyridine derivatives under mild and heterogeneous conditions in excellent yields.

  在湿的SiO 2存在下，将甲磺酸和亚硝酸钠的混合物用作有效的氧化剂，用于在温和和非均相条件下以极好的收率将1,4-二氢吡啶氧化为相应的吡啶衍生物。
• Efficient Oxidation of Hantzsch 1,4-Dihydropyridines with Nicotinium Dichromate
  作者：M. M. Sadeghi、I. Mohammadpoor-Baltork、H. R. Memarian、S. Sobhani

  DOI：10.1080/00397910008087204

  日期：2000.4.1

  A convenient method for the oxidation of various 4-substituted Hantzsch 1,4-dihydropyridines with nicotinium dichromate (NDC) in refluxing acetonitrile is reported. The yields obtained are excellent.
• Mohammadpoor-Baltork, Iraj; Sadeghi, Majid M. M.; Memarian, Hamid Reza, Journal of Chemical Research, 2000, vol. 2000, # 1, p. 40 - 41
  作者：Mohammadpoor-Baltork, Iraj、Sadeghi, Majid M. M.、Memarian, Hamid Reza、Pairow, Raihaneh

  DOI：——

  日期：——
• AROMATIZATION OF HANTZSCH 1,4-DIHYDROPYRIDINES USING BARIUM MANGANATE
  作者：Hamid R. Memarian、Majid M. Sadeghi、Ahmad R. Momeni

  DOI：10.1081/scc-100104821

  日期：2001.1

  Barium manganate has been used as an inexpensive and convenient reagent for efficient oxidation of a variety of 1,4-dihydropyridine derivatives to pyridine derivatives in refluxing benzene with excellent yields.
• Silica Chloride/NaNO 2 as a Novel Heterogeneous System for the Oxidation of 1,4-Dihydropyridines Under Mild Conditions via In Situ Generation of NOCl
  作者：Mohammad Ali Zolfigol、Farhad Shirini、Arash Ghorbani Choghamarani、Iraj Mohammadpoor-Baltork

  DOI：10.1080/10426500307836

  日期：2003.8.1

  A combination of silica chloride and sodium nitrite in the presence of wet SiO2 were used as an effective oxidizing agent for the oxidation of dihydropyridines to their corresponding pyridine derivatives under mild and heterogeneous conditions in moderate to excellent yields.