[(Z)-[amino-[4-[(Z)-N'-[2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidoyl]oxycarbamimidoyl]phenyl]methylidene]amino] 2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(Z)-[amino-[4-[(Z)-N'-[2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidoyl]oxycarbamimidoyl]phenyl]methylidene]amino] 2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidate
• 化学式: C₂₀H₁₀F₁₈N₆O₄
• 分子量: 740.308
• InChiKey: IGEUROFDLXFXHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  48
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  26

反应信息

• 作为反应物：
  描述：

  [(Z)-[amino-[4-[(Z)-N'-[2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidoyl]oxycarbamimidoyl]phenyl]methylidene]amino] 2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidate 在 吡啶 、 Heptanoylfluorid 作用下， 反应 2.0h， 以97%的产率得到5-[difluoro-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)methyl]-3-[4-[5-[difluoro-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)methyl]-1,2,4-oxadiazol-3-yl]phenyl]-1,2,4-oxadiazole
  参考文献：
  名称：

  Reaction of perfluorinated nitriles with benz-and terephthalamidoximes for the isolation of mixed 1,2,4-oxadiazoles

  摘要：

  The reaction of perfluorinated nitriles with benz- and terephthalamidoximes afforded amidoximimidates which can form mixed 1,2,4-oxadiazoles in high yield under mild conditions by the action of acid fluorides of perfluorocarboxylic acids. The structure of the compounds obtained was confirmed by the methods of C-13, F-19, and H-1 NMR, and by IR spectroscopy.

  DOI：

  10.1007/bf00864345
• 作为产物：
  描述：

  1,4-二甲胺肟苯 、 2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)acetonitrile 在 吡啶 作用下， 反应 1.0h， 以94%的产率得到[(Z)-[amino-[4-[(Z)-N'-[2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidoyl]oxycarbamimidoyl]phenyl]methylidene]amino] 2,2-difluoro-2-(2,3,3,4,4,5,5-heptafluorooxolan-2-yl)ethanimidate
  参考文献：
  名称：

  Reaction of perfluorinated nitriles with benz-and terephthalamidoximes for the isolation of mixed 1,2,4-oxadiazoles

  摘要：

  The reaction of perfluorinated nitriles with benz- and terephthalamidoximes afforded amidoximimidates which can form mixed 1,2,4-oxadiazoles in high yield under mild conditions by the action of acid fluorides of perfluorocarboxylic acids. The structure of the compounds obtained was confirmed by the methods of C-13, F-19, and H-1 NMR, and by IR spectroscopy.

  DOI：

  10.1007/bf00864345

文献信息

• BACTERIAL EFFLUX PUMP INHIBITORS FOR THE TREATMENT OF OPHTHALMIC AND OTIC INFECTIONS
  申请人：Bostian Keith

  公开号：US20080132457A1

  公开（公告）日：2008-06-05

  Efflux pump inhibitors are co-administered with antimicrobial agents for the treatment of ophthalmic or otic infections. The agents may be co-administered directly to the site of infection (e.g., the eye or ear).

  流出泵抑制剂与抗微生物药物一起联合使用，用于治疗眼科或耳科感染。这些药物可以直接共同应用于感染部位（例如眼睛或耳朵）。
• US7947741B2
  申请人：——

  公开号：US7947741B2

  公开（公告）日：2011-05-24
• US7994225B2
  申请人：——

  公开号：US7994225B2

  公开（公告）日：2011-08-09
• Reaction of perfluorinated nitriles with benz-and terephthalamidoximes for the isolation of mixed 1,2,4-oxadiazoles
  作者：E. V. Kabakchi、V. V. Il'in、A. V. Ignatenko、V. A. Ponomarenko

  DOI：10.1007/bf00864345

  日期：1992.8

  The reaction of perfluorinated nitriles with benz- and terephthalamidoximes afforded amidoximimidates which can form mixed 1,2,4-oxadiazoles in high yield under mild conditions by the action of acid fluorides of perfluorocarboxylic acids. The structure of the compounds obtained was confirmed by the methods of C-13, F-19, and H-1 NMR, and by IR spectroscopy.