5-[pyrrolidin-3-yl]-1H-pyrazole

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-[pyrrolidin-3-yl]-1H-pyrazole
• 英文别名: 5-[(3S)-pyrrolidin-3-yl]-1H-pyrazole
• 化学式: C₇H₁₁N₃
• 分子量: 137.184
• InChiKey: NQUKCXGPCOPNRA-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  40.7
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4-nitrophenyl) 3-[4-(2-methylazetidin-1-yl)phenyl]azetidine-1-carboxylate 、 5-[pyrrolidin-3-yl]-1H-pyrazole 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以18.1 %的产率得到
  参考文献：
  名称：

  NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS

  摘要：

  The present invention provides compounds of formula (I) CB (I) or pharmaceutically acceptable salts thereof, wherein R3to R5, R4a, B and C are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

  公开号：

  WO2023247670A1
• 作为产物：
  描述：

  3-(pyrrolidin-3-yl)-1H-pyrazole hydrochloride 在 ammonium hydroxide 作用下， 以 二氧化碳 、 异丙醇 为溶剂， 生成 5-[pyrrolidin-3-yl]-1H-pyrazole 、 (R)-5-[pyrrolidin-3-yl]-1H-pyrazole
  参考文献：
  名称：

  NEW HETEROCYCLIC-CARBONYL-CYCLIC COMPOUNDS AS MAGL INHIBITORS

  摘要：

  The present invention provides compounds of formula (I) CB (I) or pharmaceutically acceptable salts thereof, wherein R3to R5, R4a, B and C are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

  公开号：

  WO2023247670A1

文献信息

• Biaryl inhibitors of bruton's tyrosine kinase
  申请人：BIOGEN MA INC.

  公开号：US10081619B2

  公开（公告）日：2018-09-25

  The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

  本发明提供了可用作布鲁顿酪氨酸激酶抑制剂并表现出理想特性的化合物及其组合物。
• Biaryl inhibitors of Bruton'S tyrosine kinase
  申请人：BIOGEN MA INC.

  公开号：US10759783B2

  公开（公告）日：2020-09-01

  The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

  本发明提供了可用作布鲁顿酪氨酸激酶抑制剂并表现出理想特性的化合物及其组合物。
• BIARYL INHIBITORS OF BRUTON'S TYROSINE KINASE
  申请人：Biogen MA Inc.

  公开号：US20160311802A1

  公开（公告）日：2016-10-27

  The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
• US9809577B2
  申请人：——

  公开号：US9809577B2

  公开（公告）日：2017-11-07