(+)-(S)-2-dimethyl-2-methoxy-2-phenylethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+)-(S)-2-dimethyl-2-methoxy-2-phenylethylamine
• 英文别名: (2S)-2-methoxy-N,N-dimethyl-2-phenylethanamine
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: OEZZFHANQAGLDU-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S)-2-二甲基氨基-1-苯基乙醇 、 碘甲烷 在 sodium hydride 作用下， 生成 (+)-(S)-2-dimethyl-2-methoxy-2-phenylethylamine
  参考文献：
  名称：

  Enantioselective reaction of an imine with methyllithium catalyzed by a chiral ligand

  摘要：

  Enantioselective reaction of benzaldehyde 4-anisidineimine 1 with methyllithium in toluene was mediated by a series of chiral aminoethers 3-11 to give the corresponding amine 2 in good to moderate ee. The chiral tridentate aminoethers 7-11 are superior to the bidentate ligands 3-6, Lithium bromide affects significantly the enantioselectivity in the catalytic reaction, but not in the stoichiometric reaction.

  DOI：

  10.1016/0957-4166(95)00331-i

文献信息

• Enantioselective reaction of an imine with methyllithium catalyzed by a chiral ligand
  作者：Isao Inoue、Mitsuru Shindo、Kenji Koga、Motomu Kanai、Kiyoshi Tomioka

  DOI：10.1016/0957-4166(95)00331-i

  日期：1995.10

  Enantioselective reaction of benzaldehyde 4-anisidineimine 1 with methyllithium in toluene was mediated by a series of chiral aminoethers 3-11 to give the corresponding amine 2 in good to moderate ee. The chiral tridentate aminoethers 7-11 are superior to the bidentate ligands 3-6, Lithium bromide affects significantly the enantioselectivity in the catalytic reaction, but not in the stoichiometric reaction.