(R)-Hydroxy-(4'-methyl-biphenyl-4-yl)-acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-Hydroxy-(4'-methyl-biphenyl-4-yl)-acetic acid
• 英文别名: (2R)-2-hydroxy-2-[4-(4-methylphenyl)phenyl]acetic acid
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: JTFYNFJYJOAFJG-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (R)-2-溴氯扁桃酸 、 4-甲苯硼酸 在 palladium on activated charcoal sodium carbonate 作用下， 以 异丙醇 为溶剂， 以90%的产率得到(R)-Hydroxy-(4'-methyl-biphenyl-4-yl)-acetic acid
  参考文献：
  名称：

  Preparation of enantiopure 4-arylmandelic acids via a Pd/C catalysed Suzuki coupling of enantiopure 4-bromomandelic acid

  摘要：

  A library of enantiomerically pure mandelic acid derivatives has been prepared using a palladium on carbon catalysed Suzuki reaction. The chirality was derived from enantiomerically pure 4-bromomandelic acid which was obtained by resolution with alpha -methylbenzylamine. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02304-2

文献信息

• Preparation of enantiopure 4-arylmandelic acids via a Pd/C catalysed Suzuki coupling of enantiopure 4-bromomandelic acid
  作者：Ulrich C Dyer、Peter D Shapland、Peter D Tiffin

  DOI：10.1016/s0040-4039(00)02304-2

  日期：2001.2

  A library of enantiomerically pure mandelic acid derivatives has been prepared using a palladium on carbon catalysed Suzuki reaction. The chirality was derived from enantiomerically pure 4-bromomandelic acid which was obtained by resolution with alpha -methylbenzylamine. (C) 2001 Elsevier Science Ltd. All rights reserved.