3-Methyl-5-(trifluoromethyl)benzyl bromide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Methyl-5-(trifluoromethyl)benzyl bromide
• 英文别名: 1-(bromomethyl)-3-methyl-5-(trifluoromethyl)benzene
• 化学式: C₉H₈BrF₃
• 分子量: 253.06
• InChiKey: GZJBZDJGNUXMNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-二甲基-5-(三氟甲基)苯 、 过氧化苯甲酰 、 N-溴代丁二酰亚胺(NBS) 、 碘化钾 在 正己烷 作用下， 以 苯 为溶剂， 生成 3-Methyl-5-(trifluoromethyl)benzyl bromide
  参考文献：
  名称：

  5-Amino or substituted amino 1,2,3-triazoles

  摘要：

  揭示了具有抗球虫活性的新型5-氨基或取代氨基1,2,3-三唑化合物。这些化合物在与动物食物混合后，通常以微量给予动物，特别是家禽，可用于控制球虫病。

  公开号：

  US04816469A1

文献信息

• INHIBITORS OF STEAROYL-COA DESATURASE
  申请人：Gillespie Paul

  公开号：US20090149466A1

  公开（公告）日：2009-06-11

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

  提供以下式(I)化合物： 以及药用可接受的盐，其中取代基如说明书中所披露。这些化合物以及包含它们的药物组合物可用于治疗诸如肥胖等疾病。
• 5-amino or substituted amino 1,2,3-triazoles
  申请人：Merck & Co., Inc.

  公开号：US04950673A1

  公开（公告）日：1990-08-21

  Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with animal sustenance.

  本发明揭示了具有抗球虫活性的新型5-氨基或取代氨基1,2,3-三唑化合物。这些化合物在与动物食物混合后，以少量给予动物，尤其是家禽，有助于控制球虫病。
• Imidazo 4,5-C Pyridine Compounds and Methods of Antiviral Treatment
  申请人：Bondy S. Steven

  公开号：US20070244148A1

  公开（公告）日：2007-10-18

  The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general formula (Z): The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.

  本发明涉及一种用于治疗或预防病毒感染的药物组合物，其包含至少一种具有以下通式（Z）的咪唑[4,5-c]吡啶前药作为活性成分：本发明还涉及制备符合上述通式的化合物的方法以及它们作为药物或用于治疗或预防病毒感染的用途。
• IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT
  申请人：Bondy Steven S.

  公开号：US20100028301A1

  公开（公告）日：2010-02-04

  The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及一种制备用于治疗或预防病毒感染的药物组合物，其包含至少一种咪唑并[4,5-c]吡啶前药作为活性成分，其通式为（A），其中取代基在规范中描述。该发明还涉及根据上述通式制备和筛选化合物的方法以及它们在治疗或预防病毒感染中的应用。
• METHOD FOR PREPARING 5-[2-(METHYLTHIO)ETHOXY]PYRIMIDINE-2-AMINE
  申请人：Yamazaki Koichi

  公开号：US20110166351A1

  公开（公告）日：2011-07-07

  A novel method for preparing 5-[2-(methylthio)ethoxy]pyrimidin-2-amine useful as a regent or raw material for manufacture of medicaments, agricultural chemicals, and industrial products, which comprises alkanoylating the amino group of a 2-amino-4-alkoxypyrimidine, then converting the resultant into a 4-hydroxypyrimidine compound by a treatment with anhydrous aluminum chloride, further etherifying the 4-hydroxypyrimidine compound by a reaction with a 2-haloethyl methyl sulfide in the presence of a base, and removing the alkanoyl group to obtain 5-[2-(methylthio)ethoxy]pyrimidin-2-amine.

  一种制备5-[2-(甲硫基)乙氧基]嘧啶-2-胺的新方法，该方法可用于制造药物、农业化学品和工业产品的试剂或原料。该方法包括将2-氨基-4-烷氧基嘧啶的氨基基团进行烷酰化处理，然后通过与无水氯化铝处理将其转化为4-羟基嘧啶化合物，进一步在碱的存在下通过与2-卤代乙基甲硫醚反应将4-羟基嘧啶化合物进行醚化，最后去除烷酰基以获得5-[2-(甲硫基)乙氧基]嘧啶-2-胺。