Benzene-1,3-dicarboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzene-1,3-dicarboximidamide
• 化学式: C₈H₁₀N₄
• 分子量: 162.19
• InChiKey: AACPSQPYILEIRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  99.7
• 氢给体数：
  4
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Benzene-1,3-dicarboximidamide 以8%的产率得到
  参考文献：
  名称：

  Zuev Peter S., Sheridan Robert S., J. Org. Chem, 59 (1994) N 8, S 2267- 2269

  摘要：

  DOI：

文献信息

• Organic Compound, Light-Emitting Element, Display Module, Lighting Module, Light-Emitting Device, Display Device, Electronic Device, and Lighting Device
  申请人：Semiconductor Energy Laboratory Co., Ltd.

  公开号：US20160190471A1

  公开（公告）日：2016-06-30

  An object is to provide an organic compound having high heat resistance and a light-emitting element, a light-emitting device, an electronic device, and a display device each having high reliability. Provided are an organic compound having a 2,2′-(pyridine-2,6-diyl)bipyrimidine skeleton in which the 2-positions of pyrimidine skeletons are bonded to the 2- and 6-positions of a pyridine skeleton, and having a structure in which at least one aryl group having a fused structure with 10 to 16 carbon atoms is bonded to the 2,2′-(pyridine-2,6-diyl)bipyrimidine skeleton, and a light-emitting element, a light-emitting device, an electronic device, and a display device each containing the organic compound.

  提供一种具有高热稳定性的有机化合物和一种发光元素，以及具有高可靠性的发光器件、电子器件和显示器件的目的。提供了一种具有2,2'-(吡啶-2,6-二基嘧啶)骨架的有机化合物，其中嘧啶骨架的2位与吡啶骨架的2位和6位相连接，并且至少有一个具有10到16个碳原子的融合结构的芳基基团连接到2,2'-(吡啶-2,6-二基嘧啶)骨架，以及包含该有机化合物的发光元素、发光器件、电子器件和显示器件。
• COMBINATIONS (CATECHINS AND METHOTREXATE) FOR USE IN THE TREATMENT OF MELANOMAS
  申请人：Universidad de Murcia

  公开号：EP2887937A1

  公开（公告）日：2015-07-01
• US9929352B2
  申请人：——

  公开号：US9929352B2

  公开（公告）日：2018-03-27
• [EN] MELANOSOME TRANSPORT INHIBITION FOR THE TREATMENT OF MELANOMA<br/>[FR] INHIBITION DE TRANSPORT DE MÉLANOSOME POUR LE TRAITEMENT DU MÉLANOME
  申请人：UNIV MURCIA

  公开号：WO2014012902A2

  公开（公告）日：2014-01-23

  This invention relates to methods of increased the sensitivity of cancers, such as melanoma, to cytotoxic anti-cancer compounds, such as methotrexate, by inhibiting melanosome trafficking in the cancer cells, for example using Akt2 signalling inhibitors, such as 7-hydroxystraurosporine. Methods of treatment and compounds for use therein are provided.
• [EN] COMBINATIONS (CATECHINS AND METHOTREXATE) FOR USE IN THE TREATMENT OF MELANOMAS<br/>[FR] COMBINAISONS (CATÉCHINES ET MÉTHOTREXATE) UTILISABLES DANS LE TRAITEMENT DE MÉLANOMES
  申请人：UNIV MURCIA

  公开号：WO2014029669A1

  公开（公告）日：2014-02-27

  The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as MTX, and a tyrosinase-activated prodrug, such as TMECG or TMCG, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof. Further provided is a method of treatment of melanoma comprising administering a tyrosinase expression enhancer and a tyrosinase-activated prodrug to an individual in need thereof, wherein the individual has a melanoma in which one or more of BRAF, NRAS, p53, GNAQ, EGFR, PDGFR, RAC or c-kit carries a mutation.