N-(3-(6-((3-fluoro-5-hydroxy-4-morpholinophenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(3-(6-((3-fluoro-5-hydroxy-4-morpholinophenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide
• 英文别名: N-[3-[6-(3-fluoro-5-hydroxy-4-morpholin-4-ylanilino)-1-(oxan-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]phenyl]prop-2-enamide
• 化学式: C₂₉H₃₀FN₇O₄
• 分子量: 559.6
• InChiKey: ABWBGNXZYSHXAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  N-(3-(6-chloro-1-(terahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide 、 5-Amino-3-fluoro-2-morpholinophenol 在 钯 作用下， 以to yield N-(3-(6-((3-fluoro-5-hydroxy-4-morpholinophenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide, which的产率得到N-(3-(6-((3-fluoro-5-hydroxy-4-morpholinophenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)phenyl)acrylamide
  参考文献：
  名称：

  Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors

  摘要：

  在一个方面，本发明涉及替代的N-(3-(嘧啶-4-基)苯基)丙烯酰胺类似物、其衍生物和相关化合物，它们可用作BTK激酶的抑制剂；制备这些化合物的合成方法；包括这些化合物的药物组合物；以及使用这些化合物和组合物治疗与BTK激酶功能障碍相关的疾病的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。

  公开号：

  US09296703B2

文献信息

• Substituted N-(3-(Pyrimidin-4-YL)Phenyl)Acrylamide Analogs as Tyrosine Receptor Kinase BTK Inhibitors
  申请人：UNIVERSITY OF UTAH RESEARCH FOUNDATION

  公开号：US20150368208A1

  公开（公告）日：2015-12-24

  In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在某个方面，本发明涉及取代的N-(3-(嘧啶-4-基)苯基)丙烯酰胺类似物、其衍生物和相关化合物，它们作为BTK激酶抑制剂是有用的；制备这些化合物的合成方法；包括这些化合物的制药组合物；以及使用这些化合物和组合物治疗与BTK激酶功能障碍相关的疾病的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。
• SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS
  申请人：University of Utah Research Foundation

  公开号：EP2903971B1

  公开（公告）日：2019-06-12
• US9296703B2
  申请人：——

  公开号：US9296703B2

  公开（公告）日：2016-03-29
• [EN] SUBSTITUTED N-(3-(PYRIMIDIN-4-YL)PHENYL)ACRYLAMIDE ANALOGS AS TYROSINE RECEPTOR KINASE BTK INHIBITORS<br/>[FR] ANALOGUES DE N-(3-(PYRIMIDIN-4-YL)PHÉNYL) SUBSTITUÉ UTILISÉS EN TANT QU'INHIBITEURS DE RÉCEPTEUR TYROSINE KINASE BTK
  申请人：UNIV UTAH RES FOUND

  公开号：WO2014055934A2

  公开（公告）日：2014-04-10

  In one aspect, the invention relates to substituted N-(3-(pyrimidin-4- yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors
  申请人：University of Utah Research Foundation

  公开号：US09296703B2

  公开（公告）日：2016-03-29

  In one aspect, the invention relates to substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the BTK kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the BTK kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，本发明涉及替代的N-(3-(嘧啶-4-基)苯基)丙烯酰胺类似物、其衍生物和相关化合物，它们可用作BTK激酶的抑制剂；制备这些化合物的合成方法；包括这些化合物的药物组合物；以及使用这些化合物和组合物治疗与BTK激酶功能障碍相关的疾病的方法。本摘要旨在作为搜索特定领域的扫描工具，不限制本发明。