N-(3-chloro-4-fluorophenyl)-t-butylamide | 123682-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-chloro-4-fluorophenyl)-t-butylamide
• 英文别名: 3-chloro-4-fluoroisobutyrylanilide；N-(3-chloro-4-fluorophenyl)-2-methylpropanamide
• CAS: 123682-37-1
• 化学式: C₁₀H₁₁ClFNO
• mdl: MFCD01182231
• 分子量: 215.655
• InChiKey: JDIPYEUUBFBRJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯-4-氟苯胺 、 异丁酰氯 在 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 以103%的产率得到N-(3-chloro-4-fluorophenyl)-t-butylamide
  参考文献：
  名称：

  Novel imidate insecticides

  摘要：

  一系列新型咪唑类杀虫剂，其通用结构式为##STR1##其中R.sub.1是可选择取代的芳基，取代基包括卤素、C.sub.1 -C.sub.4 烷基、C.sub.1 -C.sub.4 卤代烷氧基、C.sub.1 -C.sub.4 烷氧基、C.sub.1 -C.sub.4 卤代烷硫基、C.sub.3 -C.sub.6 环烷基、硝基、C.sub.1 -C.sub.4 卤代烷基、C.sub.2 -C.sub.5 羧酰氧基、C.sub.1 -C.sub.4 烷硫基、氰基、C.sub.1 -C.sub.4 烷基磺酰基、C.sub.2 -C.sub.4 卤代烷基磺酰基；C.sub.2 -C.sub.5 烷基羰基、C.sub.2 -C.sub.4 烷基氧基、C.sub.1 -C.sub.2 全氟烷基氧基；C.sub.1 -C.sub.4 烷二氧基、C.sub.1 -C.sub.3 卤代烷二氧基、苯基、单取代苯基、吡啶氧基、C.sub.2 -C.sub.4 烷基、C.sub.2 -C.sub.4 烯基、C.sub.3 -卤代烯氧基；和/或酰胺；R.sub.2是C.sub.1 -C.sub.7 烷基、C.sub.1 -C.sub.6 卤代烷基、环丙基、环丁基、单取代或多取代卤代或甲基取代的环丙基、氰基、C.sub.2 -C.sub.4 烷氧基烷基、C.sub.2 -C.sub.6 卤代烯基或C.sub.2 -C.sub.6 烯基；R.sub.3是(a)可选择取代的3-苯氧基苯丙基、3-苯氧基吡啶基丙基、3-(吡啶氧基)苯丙基、3-苯胺基苯丙基、3-苄基苯丙基或苄氧基苯丙基基团；(b)苄呋喃基甲基；(c)3-或4-取代苄基或四氟苄基基团；(d)4-苯氧基-2-丁炔-2-基；(e)2-甲基-3-苯基苄基，或(f)4-(4-三氟甲基-2-吡啶氧基)苄基。

  公开号：

  US05045566A1

文献信息

• QUINOLINE INHIBITORS OF RAD52 AND METHODS OF USE
  申请人：Drexel University

  公开号：US20220388980A1

  公开（公告）日：2022-12-08

  The present disclosure related to compounds of Formula I and Formula I and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating RAD52 activity and may be used in the treatment of disorders in which RAD52 activity is implication, such as a cancer.
• Novel imidate insecticides
  申请人：ICI Americas Inc.

  公开号：US05045566A1

  公开（公告）日：1991-09-03

  A series of novel imidate insecticides distinguished by the general formula ##STR1## in which R.sub.1 is an optionally substituted aryl group in which the substituents are halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkylthio, C.sub.3 -C.sub.6 cycloalkyl, nitro, C.sub.1 -C.sub.4 haloalkyl, C.sub.2 -C.sub.5 carboalkoxy, C.sub.1 -C.sub.4 alkylthio, cyano, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.2 -C.sub.4 haloalkylsulfonyl; C.sub.2 -C.sub.5 alkylcarbonyl, C.sub.2 -C.sub.4 alkyleneoxy, C.sub.1 -C.sub.2 perhaloalkyleneoxy; C.sub.1 -C.sub.4 alkylendioxy, C.sub.1 -C.sub.3 halo-substituted alkylenedioxy, phenyl, mono-substituted phenyl, pyridyloxy, C.sub.2 -C.sub.4 alkylene, C.sub.2 -C.sub.4 alkenyl, C.sub.3 -haloalkenoxy; and/or amido; R.sub.2 is C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.6 haloalkyl, cyclopropyl, cyclobutyl, mono- or poly- halo- or methyl-substituted cyclopropyl, cyano, C.sub.2 -C.sub.4 alkoxyalkyl, C.sub.2 -C.sub.6 haloalkenyl or C.sub.2 -C.sub.6 alkenyl; and R.sub.3 is (a) an optionally substituted 3-phenoxyphenalkyl, 3-phenoxypyridylalkyl, 3-(pyridyloxy)phenalkyl, 3-phenylaminophenalkyl, 3-benzylphenalkyl or benzyloxyphenalkyl moiety; (b) a benzylfuranylmethyl moiety; (c) a 3- or 4-substituted benzyl or tetrafluorobenzyl moiety; (d) 4-phenoxy-2-butyn-2-yl; (e) 2-methyl-3-phenylbenzyl, or (f) 4-(4-trifluoromethyl-2-pyridyloxy)benzyl.

  一系列新型咪唑类杀虫剂，其通用结构式为##STR1##其中R.sub.1是可选择取代的芳基，取代基包括卤素、C.sub.1 -C.sub.4 烷基、C.sub.1 -C.sub.4 卤代烷氧基、C.sub.1 -C.sub.4 烷氧基、C.sub.1 -C.sub.4 卤代烷硫基、C.sub.3 -C.sub.6 环烷基、硝基、C.sub.1 -C.sub.4 卤代烷基、C.sub.2 -C.sub.5 羧酰氧基、C.sub.1 -C.sub.4 烷硫基、氰基、C.sub.1 -C.sub.4 烷基磺酰基、C.sub.2 -C.sub.4 卤代烷基磺酰基；C.sub.2 -C.sub.5 烷基羰基、C.sub.2 -C.sub.4 烷基氧基、C.sub.1 -C.sub.2 全氟烷基氧基；C.sub.1 -C.sub.4 烷二氧基、C.sub.1 -C.sub.3 卤代烷二氧基、苯基、单取代苯基、吡啶氧基、C.sub.2 -C.sub.4 烷基、C.sub.2 -C.sub.4 烯基、C.sub.3 -卤代烯氧基；和/或酰胺；R.sub.2是C.sub.1 -C.sub.7 烷基、C.sub.1 -C.sub.6 卤代烷基、环丙基、环丁基、单取代或多取代卤代或甲基取代的环丙基、氰基、C.sub.2 -C.sub.4 烷氧基烷基、C.sub.2 -C.sub.6 卤代烯基或C.sub.2 -C.sub.6 烯基；R.sub.3是(a)可选择取代的3-苯氧基苯丙基、3-苯氧基吡啶基丙基、3-(吡啶氧基)苯丙基、3-苯胺基苯丙基、3-苄基苯丙基或苄氧基苯丙基基团；(b)苄呋喃基甲基；(c)3-或4-取代苄基或四氟苄基基团；(d)4-苯氧基-2-丁炔-2-基；(e)2-甲基-3-苯基苄基，或(f)4-(4-三氟甲基-2-吡啶氧基)苄基。