N,4-diphenyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,4-diphenyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide
• 英文别名: N,4-diphenyl-2-pyridin-3-yl-1,3-thiazole-5-carboxamide
• 化学式: C₂₁H₁₅N₃OS
• 分子量: 357.4
• InChiKey: ARUCEDWVTGXZGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N,4-diphenyl-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide 、 2,4-二苯基-1,3-噻唑-5-羧酸 、 4-氟苯胺 生成 N-(4-fluorophenyl)-2,4-diphenylthiazole-5-carboxamide
  参考文献：
  名称：

  THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS

  摘要：

  本文提供的是I式化合物，以及其药学上可接受的盐，其中代换基如规范中所披露。这些化合物及其所含的药物组合物，可用于治疗退行性疾病和障碍。

  公开号：

  US20160130241A1

文献信息

• US20140275178A1
  申请人：——

  公开号：——

  公开（公告）日：——
• Compositions and Methods for the Treatment of Degenerative Diseases
  申请人：Beeson Craig Cano

  公开号：US20130137728A1

  公开（公告）日：2013-05-30

  Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating de-generative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.
• COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS
  申请人：MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

  公开号：US20160237074A1

  公开（公告）日：2016-08-18

  Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating degenerative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.
• US9850218B2
  申请人：——

  公开号：US9850218B2

  公开（公告）日：2017-12-26
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEGENERATIVE DISEASES<br/>[FR] COMPOSITIONS ET MÉTHODES DESTINÉES AU TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：UNIV SOUTH CAROLINA

  公开号：WO2011119869A1

  公开（公告）日：2011-09-29

  Disclosed are compounds or pharmaceutically acceptable salts thereof, having the structure of formula I. Also disclosed are methods of preventing and/or treating degenerative disease in a subject, comprising administering to said subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions for preventing and/or treating degenerative disease in a subject comprising a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof.