2-Biphenyl-4-yl-benzo[de]isoquinoline-1,3-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Biphenyl-4-yl-benzo[de]isoquinoline-1,3-dione
• 英文别名: 2-(4-biphenylyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione；2-(4-phenylphenyl)benzo[de]isoquinoline-1,3-dione
• 化学式: C₂₄H₁₅NO₂
• 分子量: 349.389
• InChiKey: NOVXXWHRCCQHIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,8-萘二甲酸酐 、 4-氨基联苯 在 吡啶 、 zinc diacetate 作用下， 反应 12.0h， 生成 2-Biphenyl-4-yl-benzo[de]isoquinoline-1,3-dione
  参考文献：
  名称：

  Toward intrinsically fluorescent proteomimetics: Fluorescent probe response to alpha helix structure of poly-γ-benzyl-l-glutamate

  摘要：

  A fluorescent probe (1), developed for recognition of alpha helical secondary structure, shows a large fluorescence change upon titration with the synthetic protein PBLG. Compared to fluorophores of similar size and shape, 1 displayed the smallest dissociation constant (K-D = 80 mu M) when titrated with PBLG. These preliminary studies are directed toward developing small molecule proteomimetics that have intrinsic fluorescence and are specific for helical-protein binding-sites. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.07.050

文献信息

• Toward intrinsically fluorescent proteomimetics: Fluorescent probe response to alpha helix structure of poly-γ-benzyl-l-glutamate
  作者：Kenji Hutt、Randy Hernandez、Michael D. Heagy

  DOI：10.1016/j.bmcl.2006.07.050

  日期：2006.10

  A fluorescent probe (1), developed for recognition of alpha helical secondary structure, shows a large fluorescence change upon titration with the synthetic protein PBLG. Compared to fluorophores of similar size and shape, 1 displayed the smallest dissociation constant (K-D = 80 mu M) when titrated with PBLG. These preliminary studies are directed toward developing small molecule proteomimetics that have intrinsic fluorescence and are specific for helical-protein binding-sites. (c) 2006 Elsevier Ltd. All rights reserved.