2-氨基-N-(4-乙氧苯基)苯甲酰胺 | 19562-43-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氨基-N-(4-乙氧苯基)苯甲酰胺
• 中文别名: 2-氨基-N-(4-乙氧基苯基)-苯甲酰胺
• 英文名称: Anthranilic acid 4-phenetidide
• 英文别名: 2-amino-N-(4-ethoxyphenyl)benzamide；2-Amino-benzoesaeure-<4-aethoxy-anilid>
• CAS: 19562-43-7
• 化学式: C₁₅H₁₆N₂O₂
• mdl: MFCD00578809
• 分子量: 256.304
• InChiKey: BSWXUOKYYNLILZ-UHFFFAOYSA-N

物化性质

• 熔点：
  130 °C
• 沸点：
  363.4±27.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-氨基-N-(4-乙氧苯基)苯甲酰胺 在 吡啶 作用下， 反应 1.0h， 生成 2-[Acetyl-(4-nitro-benzyl)-amino]-N-(4-ethoxy-phenyl)-benzamide
  参考文献：
  名称：

  4(3H)quinazolones. XII. Synthesis and biological activity of 1-benzyl(4′-nitrobenzyl)-2-methyl-3-alkyl(aryl)-4(3h)quinazolinonium perchlorates

  摘要：

  DOI：

  10.1007/bf00769805
• 作为产物：
  描述：

  靛红酸酐 、 对乙氧基苯胺 反应 2.0h， 生成 2-氨基-N-(4-乙氧苯基)苯甲酰胺
  参考文献：
  名称：

  喹唑啉酮胆囊收缩素-B受体配体。

  摘要：

  DOI：

  10.1021/jm00108a040

文献信息

• Pyrimidinone compounds
  申请人：Lin Chu-Chung

  公开号：US20060036093A1

  公开（公告）日：2006-02-16

  This invention relates to treating inflammatory and immune diseases with certain pyrimidinone compounds that bind to CXCR3 receptors. The pyrimidinone compounds are covered by the formula (I) shown below. Each variable is defined in the specification.

  这项发明涉及使用与CXCR3受体结合的某些嘧啶酮化合物治疗炎症和免疫性疾病。这些嘧啶酮化合物由下面所示的公式（I）覆盖。每个变量在说明书中有定义。
• Thiourea derivatives incorporating a hippuric acid moiety: Synthesis and evaluation of antibacterial and antifungal activities
  作者：Samir Y. Abbas、Marwa A.M.Sh. El-Sharief、Wahid M. Basyouni、Issa M.I. Fakhr、Eman W. El-Gammal

  DOI：10.1016/j.ejmech.2013.04.002

  日期：2013.6

  New series of thiourea derivatives incorporating a hippuric acid moiety have been synthesized through the reaction of 4-hippuric acid isothiocyanate with various nitrogen nucleophiles such as aliphatic amines, aromatic amines, sulfa drugs, aminopyrazoles, phenylhydrazine and hydrazides. The synthesized compounds were tested against bacterial and fungal strains. Most of compounds, such as 2-(4-(3-(

  通过使4-庚酸异硫氰酸酯与各种氮亲核试剂如脂肪族胺，芳族胺，磺胺类药物，氨基吡唑，苯肼和酰肼反应，已合成了结合有马尿酸部分的新系列硫脲衍生物。测试了合成化合物的抗细菌和真菌菌株。大多数化合物，例如2-（4-（3-（3-溴苯基）硫脲基）苯甲酰胺基）乙酸和2-（4-（3-（4-（N-嘧啶-2-基氨磺酰基）苯基）硫脲基）苯甲酰氨基）乙酸，具有显着的抗菌和抗真菌活性。这些化合物包括一类新的有前景的广谱抗菌和抗真菌剂。
• CXCR3 antagonists
  申请人：Tularik Inc.

  公开号：US20020169159A1

  公开（公告）日：2002-11-14

  Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

  本文提供了在治疗炎症和免疫疾病中有用的化合物、组合物和方法。特别地，本发明提供了调节趋化因子受体表达和/或功能的化合物。这些方法适用于治疗炎症和免疫调节性疾病，例如多发性硬化症、类风湿性关节炎和1型糖尿病。
• Substituted pyrido[2,3-d]pyrimidines and methods for their use
  申请人：Huang Alan Xi

  公开号：US06964967B2

  公开（公告）日：2005-11-15

  Compounds having the formula: wherein A 4 is N and X is —C(O)— or —CH 2 —, are provided, which are useful as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.

  提供了具有以下公式的化合物：其中A4为N，X为—C（O）—或—CH2—，它们可用作趋化因子受体的调节剂，用于治疗炎症和免疫调节性疾病。还提供了用于治疗炎症和免疫调节性疾病（如多发性硬化症、类风湿性关节炎和1型糖尿病）的这些化合物的制药组合物和使用方法。
• Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use
  申请人：Amgen SF, LLC

  公开号：US07053215B2

  公开（公告）日：2006-05-30

  Compounds are provided that have the formula: where X, A4, Ra, R1, R2, R3, R4, R14, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.

  提供具有以下式子的化合物：其中X、A4、Ra、R1、R2、R3、R4、R14、L和Q的描述如下。例如，这些化合物可用作趋化因子受体的调节剂，用于治疗炎症和免疫调节性疾病。还提供了用于治疗炎症和免疫调节性疾病（如多发性硬化症、类风湿性关节炎和1型糖尿病）的这些化合物的药物组合物和使用方法。