(S)-Methyl Oxazaborolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-Methyl Oxazaborolidine
• 英文别名: 1-methyl-3,3-diphenyl-3a,4,5,6-tetrahydropyrrolo[1,2-c][1,3,2]oxazaborole
• 化学式: C18H20BNO
• 分子量: 277.2
• InChiKey: VMKAFJQFKBASMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-Methyl Oxazaborolidine 、 1-(2-Oxo-4-phenyloxazolidin-3-yl)-5-phenylpentane-1,5-dione 以by the same route, 3 is obtained in diastereomerically enriched form的产率得到3-(5-羟基-5-苯基戊酰基)-4-苯基-1,3-恶唑烷-2-酮
  参考文献：
  名称：

  Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use

  摘要：

  公式I的化合物，其中R1、R2、R3、R4、R5和R6的含义如描述中所给，并且它们的生理可接受的盐。这些化合物适用于例如作为降脂药物的用途。

  公开号：

  US06498156B2

文献信息

• 4-Biarylyl-1-phenylazetidin-2-ones
  申请人：Martinez Eduardo

  公开号：US20050209165A1

  公开（公告）日：2005-09-22

  4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.

  本文披露了用于治疗高胆固醇血症的4-联苯基-1-苯基氮杂环戊二酮。化合物的一般式如下：其中，表示芳基或杂环芳基残基；Ar表示芳基残基；U是一个由2到6个原子组成的链；R代表取代基。
• 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES
  申请人：Martinez Eduardo J.

  公开号：US20080167255A1

  公开（公告）日：2008-07-10

  4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.

  公开了用于治疗高胆固醇血症的4-双芳基-1-苯基氮杂环戊二酮。该化合物的一般式如下：其中R表示芳基或杂芳基残基；Ar表示芳基残基；U是一个由2到6个原子组成的链；R代表取代基。
• SUBSTITUTED HETEROCYCLIC ACETAMIDES AS KAPPA OPIOID RECEPTOR (KOR) AGONISTS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US20150031685A1

  公开（公告）日：2015-01-29

  The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (κ) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

  本发明涉及一系列具有一般式（I）的取代化合物，包括其立体异构体和/或其药学上可接受的盐，其中R1、R2、R3、R4、R5和R6如本文所定义。本发明还涉及制备这些化合物的方法，包括中间体。本发明的化合物在kappa (κ) 阿片受体 (KOR) 位点上具有有效性。因此，本发明的化合物在制药剂中是有用的，特别是在治疗和/或预防各种中枢神经系统疾病 (CNS) 中，包括但不限于急性和慢性疼痛及相关疾病，尤其在中枢神经系统周边的功能方面。
• Diphenylazetidinone derivatives, process for their preparation, medicaments comprising these compounds and their use
  申请人：——

  公开号：US20020128252A1

  公开（公告）日：2002-09-12

  Compounds of the formula I, 1 in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.

  公式I的化合物，其中R1、R2、R3、R4、R5和R6具有描述中给出的含义，以及它们的生理上可接受的盐。这些化合物适用于例如作为降脂药物的用途。