3,6-anhydro-alpha-L-galactopyranose | 19479-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧环庚烷
• 英文名称: 3,6-anhydro-alpha-L-galactopyranose
• 英文别名: (1S,3R,4S,5R,8R)-2,6-dioxabicyclo[3.2.1]octane-3,4,8-triol
• CAS: 19479-27-7
• 化学式: C₆H₁₀O₅
• 分子量: 162.14
• InChiKey: DCQFFOLNJVGHLW-DSOBHZJASA-N

物化性质

• 沸点：
  423.2±45.0 °C(Predicted)
• 密度：
  1.688±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,6-anhydro-alpha-L-galactopyranose 、 水 、 nicotinamide adenine dinucleotide 生成 3,6-anhydro-L-galactonate 、 氢(+1)阳离子 、 NADH
  参考文献：
  名称：

  The novel catabolic pathway of 3,6-anhydro-L-galactose, the main component of red macroalgae, in a marine bacterium

  摘要：

  SummaryThe catabolic fate of the major monomeric sugar of red macroalgae, 3,6‐anhydro‐L‐galactose (AHG), is completely unknown in any organisms. AHG is not catabolized by ordinary fermentative microorganisms, and it hampers the utilization of red macroalgae as renewable biomass for biofuel and chemical production. In this study, metabolite and transcriptomic analyses of Vibrio sp., a marine bacterium capable of catabolizing AHG as a sole carbon source, revealed two key metabolic intermediates of AHG, 3,6‐anhydrogalactonate (AHGA) and 2‐keto‐3‐deoxy‐galactonate; the corresponding genes were verified in vitro enzymatic reactions using their recombinant proteins. Oxidation by an NADP+‐dependent AHG dehydrogenase and isomerization by an AHGA cycloisomerase are the two key AHG metabolic processes. This newly discovered metabolic route was verified in vivo by demonstrating the growth of Escherichia coli harbouring the genes of these two enzymes on AHG as a sole carbon source. Also, the introduction of only these two enzymes into an ethanologenic E. coli strain increased the ethanol production in E. coli by fermenting both AHG and galactose in an agarose hydrolysate. These findings provide not only insights for the evolutionary adaptation of a central metabolic pathway to utilize uncommon substrates in microbes, but also a metabolic design principle for bioconversion of red macroalgal biomass into biofuels or industrial chemicals.

  DOI：

  10.1111/1462-2920.12607

文献信息

• Low gel strength agar-agar
  申请人：INA FOOD INDUSTRY CO., LTD.

  公开号：EP0570252A2

  公开（公告）日：1993-11-18

  According to a low gel strength agar of the invention, the molecules of agar are cut to short fragments, and the gel strength of the agar is adjusted to be 250 g/cm² or below at 1.5 % agar concentration. Thus, even when the agar is used at a certain agar concentration or above, a soft gel having a low gel strength with no syneresis can be obtained. When the agar is contained in foods or cosmetics, special advantages, which are not obtainable with prior-art products, can be achieved.

  根据本发明的低凝胶强度琼脂，琼脂分子被切割成短片，琼脂浓度为 1.5 % 时，琼脂的凝胶强度调整为 250 g/cm² 或以下。因此，即使琼脂的浓度达到或超过一定水平，也能获得凝胶强度低、无滞后的软凝胶。当食品或化妆品中含有琼脂时，可以获得现有产品无法实现的特殊优势。
• Food comprising a low gel strength agar
  申请人：INA FOOD INDUSTRY CO., LTD.

  公开号：EP0873691A2

  公开（公告）日：1998-10-28

  The invention relates to food comprising a low gel strength agar. In those foods, the molecules of agar are cut to short fragments, and the gel strength of the agar is adjusted to be 250 g/cm2 or below at 1.5% agar concentration. The agar gels are mainly used in said food as fat replacers, texture-improving agents, aging-preventing agents, or dietary fibres.

  本发明涉及含有低凝胶强度琼脂的食品。 在这些食品中，琼脂分子被切割成短小的片段，琼脂的凝胶强度被调整为 250 克/平方厘米或以下（琼脂浓度为 1.5%）。 琼脂凝胶在上述食品中主要用作脂肪替代物、质地改善剂、抗老化剂或膳食纤维。
• Electrophoresis matrix based on cross-linked double network hydrogel
  申请人：Chiari, Marcella

  公开号：EP2026063A1

  公开（公告）日：2009-02-18

  Hydrogel characterised by high mechanical stability, improved adhesion to plastic and better sieving properties, an alectrophoresis apparatus containing the same hydrogel and a method for separating macromolecules using it. The hydrogel is formed by a water-soluble polymer derivatized with allyl and/or acryloyl radicals and bearing 1,2-diol or 1,3-diol functionalities, a cross-linker and an olefinic monomer.

  机械稳定性高、与塑料的粘附性更好、筛分性能更佳的水凝胶，含有这种水凝胶的电泳仪，以及用其分离大分子的方法。这种水凝胶是由一种用烯丙基和/或丙烯酰基衍生并带有 1，2-二醇或 1，3-二醇官能团的水溶性聚合物、一种交联剂和一种烯烃单体形成的。
• Compositions and methods for modulating growth of a genetically modified gut bacterial cell
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11254918B2

  公开（公告）日：2022-02-22

  Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome.

  本发明提供了用于调节存在于人体器官中的转基因细菌细胞的生长、调节转基因细菌细胞在器官（如肠道）中的生长、取代器官中细菌细胞群的至少一部分以及促进转基因细菌细胞在肠道中定植的组合物和方法。此外，还提供了转基因细菌细胞，例如，包括异源碳水化合物利用基因或基因组的细胞，该基因或基因组具有利用稀有碳水化合物作为碳源的能力。
• Ribonucleic acid purification
  申请人：ModernaTX, Inc.

  公开号：US11377470B2

  公开（公告）日：2022-07-05

  Disclosed herein are methods for purifying RNA comprising poly A. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying RNA comprising polyA. Other embodiments are also disclosed. Commercially-available resins having polythymidine oligonucleotide ligands typically contain less than 30 thymidine (2′deoxy) residues and some commercial resin suppliers utilize a distribution of dT chain lengths, not of a discreet length.

  本文公开了纯化包含聚 A 的 RNA 的方法，还公开了用于纯化包含聚 A 的 RNA 的组合物，如表面和寡核苷酸。还公开了其他实施方案。市售的具有聚胸苷寡核苷酸配体的树脂通常含有少于 30 个胸苷（2′脱氧）残基，一些 商用树脂供应商利用 dT 链长度的分布，而不是长度的分布。