鸟苷3'-(三氢二磷酸酯),5'-(三氢二磷酸酯) | 32452-17-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 鸟苷3'-(三氢二磷酸酯),5'-(三氢二磷酸酯)
• 英文名称: guanosine 5'-diphosphate 3'-diphosphate
• 英文别名: ppGpp；Guanosine-5',3'-tetraphosphate；[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-hydroxy-2-[[hydroxy(phosphonooxy)phosphoryl]oxymethyl]oxolan-3-yl] phosphono hydrogen phosphate
• CAS: 32452-17-8
• 化学式: C₁₀H₁₇N₅O₁₇P₄
• 分子量: 603.163
• InChiKey: BUFLLCUFNHESEH-UUOKFMHZSA-N

物化性质

• 密度：
  2.85±0.1 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -7.7
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  341
• 氢给体数：
  9
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  2'-O-(tert-butyldimethylsilyl)-2-N-(dimethylaminomethylene)guanosine 在 吡啶 、 四氮唑 、 ammonium hydroxide 、 三正丁胺 、 palladium on activated carbon 、 水 、 氢气 、 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 27.5h， 生成 鸟苷3'-(三氢二磷酸酯),5'-(三氢二磷酸酯)
  参考文献：
  名称：

  PRODUCTION METHOD AND PRODUCTION INTERMEDIATE FOR GUANOSINE-3',5'-BISDIPHOSPHATE

  摘要：

  本发明涉及一种鸟苷-3′,5′-双磷酸盐的生产方法和生产中间体。

  公开号：

  US20210094980A1

文献信息

• COMPOUNDS FOR TREATING BACTERIAL INFECTIONS
  申请人：Glaser Gad

  公开号：US20110086813A1

  公开（公告）日：2011-04-14

  The present invention relates to a novel class of guanine nucleotide analogs which inhibit RelA and Relseq synthetic activity and which possess anti-bacterial activity. The present invention also relates to pharmaceutical compositions that include such compounds, and to methods of use of such compounds or compositions for combating bacteria and treating bacterial infections.

  本发明涉及一类新型鸟嘌呤核苷酸类似物，其抑制RelA和Relseq的合成活性，并具有抗细菌活性。本发明还涉及包括这些化合物的药物组合物，以及利用这些化合物或组合物来对抗细菌和治疗细菌感染的方法。
• Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family
  申请人：Filippov Dmitriy Vladimirovich

  公开号：US20080113416A1

  公开（公告）日：2008-05-15

  The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea , wherein said bacterium has attenuated expression of a gene encoding a toxin of a bacterial toxin-antitoxin pair.

  本发明提供了一种利用肠杆菌科细菌，特别是属于大肠杆菌属或泛土壤杆菌属的菌株，通过减弱编码细菌毒素-抗毒素对中毒素的基因表达，生产L-氨基酸的方法。
• Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family Having Expression of the leuO Gene Attenuated
  申请人：Rybak Konstantin Vyacheslavovich

  公开号：US20090215129A1

  公开（公告）日：2009-08-27

  The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea , which has been modified to attenuate expression of the leuO gene.

  本发明提供了一种利用Enterobacteriaceae家族的细菌，特别是属于Escherichia或Pantoea属的已经被改良以减弱leuO基因表达的细菌来生产L-氨基酸的方法。
• Spo-rel, a Staphylococcus relA/spot homologue
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0839910A2

  公开（公告）日：1998-05-06

  spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.

  公开了 spo-rel 多肽和编码这种 spo-rel 的 DNA（RNA）以及通过重组技术生产这种多肽的程序。还公开了利用这种 spo-rel治疗感染，特别是细菌感染的方法。还公开了针对这种 spo-rel 的拮抗剂及其用作治疗感染，特别是细菌感染的方法。还公开了用于检测与宿主体内存在 spo-rel核酸序列和多肽有关的疾病的诊断测定法。还公开了用于检测编码 relA/spoT 基因家族的多核苷酸和检测宿主体内多肽的诊断测定法。
• Antibiotic hypersusceptibility mutations in bacteria
  申请人：The Board of Trustees of the University of illinois

  公开号：EP1188829A2

  公开（公告）日：2002-03-20

  The present invention discloses methods for identifying loci of antibiotic hypersusceptibility mutations using random insertional mutagenesis of a bacterial population with a selectable or screenable marker, treatment of a mutagenized bacterial population with an antibacterial agent, and selection of DNA of cells affected by the antibacterial agents. In some embodiments, the DNA selected is released from bacteria lysed in response to antibacterial treatment. The selected DNA also may be released as a result of exposure to a non-lysing antibacterial agent in combination with one or more additional treatments that results in bacterial lysis. In other instances, selected DNA may be released from bacteria only as a result of insertion of a lysis gene cassette through genetic engineering of the bacteria. In some instances, the selected DNA is used to transform fresh populations of bacteria and the cycle of DNA selection and transformation is repeated as many times as needed for obtaining hypersusceptibility mutants. After the DNA of such a mutant is collected, purified and sequenced, the location of a selectable or screenable marker identifies the antibacterial hypersusceptibility locus. The proteins encoded by these loci can serve as targets for potentiators of an antibacterial agent.

  本发明公开了利用可选择或可筛选标记对细菌群体进行随机插入诱变，用抗菌剂处理诱变的细菌群体，并选择受抗菌剂影响的细胞的 DNA，从而鉴定抗生素高敏感性突变位点的方法。在某些实施方案中，所选 DNA 是在抗菌处理过程中从裂解的细菌中释放出来的。被选中的 DNA 也可能是在接触非溶解性抗菌剂并结合一种或多种额外处理导致细菌裂解后释放出来的。在其他情况下，只有通过细菌基因工程插入裂解基因盒，才能从细菌中释放出所选 DNA。在某些情况下，选定的 DNA 被用于转化新的细菌群体，DNA 的选择和转化循环根据需要重复多次，以获得高敏感性突变体。在对突变体的 DNA 进行收集、纯化和测序后，可选择或可筛选标记的位置将确定抗菌高敏感性基因座。这些基因座编码的蛋白质可作为抗菌剂增效剂的靶标。